Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection

Genome editing via CRISPR/Cas9 has become an efficient and reliable way to make precise, targeted changes to the genome of living cells. CXCR4 is a co-receptor for the human immunodeficiency virus type 1 (HIV-1) infection and has been considered as an important therapeutic target for AIDS. CXCR4 med...

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Veröffentlicht in:	Scientific reports 2015-10, Vol.5 (1), p.15577-15577, Article 15577
Hauptverfasser:	Hou, Panpan, Chen, Shuliang, Wang, Shilei, Yu, Xiao, Chen, Yu, Jiang, Meng, Zhuang, Ke, Ho, Wenzhe, Hou, Wei, Huang, Jian, Guo, Deyin
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/31 38/77 42/109 42/44 42/70 45/23 45/41 631/61/201/2110 692/699/255/1901 96/1 96/34 Acquired immune deficiency syndrome AIDS Alleles Animals Base Sequence CD4 antigen CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - virology Cell division Cell Line Cell Membrane - metabolism Cells, Cultured CRISPR CRISPR-Cas Systems - genetics CXCR4 protein Disease Resistance - genetics Gene Deletion Gene Expression Gene Targeting Genetic Loci Genome editing Genomes Glycoprotein gp120 HIV HIV Infections - genetics HIV Infections - virology HIV-1 Human immunodeficiency virus Humanities and Social Sciences Humans Infections Jurkat Cells Lymphocytes T Macaca mulatta Molecular Sequence Data multidisciplinary Receptors, CXCR4 - genetics Receptors, CXCR4 - metabolism RNA Editing Science Viral envelope proteins
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