Deep brain stimulation complicated by bilateral large cystic cavitation around the leads in a patient with Parkinson's disease
Deep brain stimulation (DBS) is an approved and effective therapy for patients suffering from advanced Parkinson's disease (PD). Several clinical trials have indicated significant motor function improvement in patients undergoing subthalamic nucleus stimulation. This therapy is, rarely, associa...
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| Veröffentlicht in: | BMJ case reports 2015-10, Vol.2015, p.bcr2015211470 |
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| creator | Jagid, Jonathan Madhavan, Karthik Bregy, Amade Desai, Mehul Ruiz, Armando Quencer, Robert Landy, Howard J |
| description | Deep brain stimulation (DBS) is an approved and effective therapy for patients suffering from advanced Parkinson's disease (PD). Several clinical trials have indicated significant motor function improvement in patients undergoing subthalamic nucleus stimulation. This therapy is, rarely, associated with complications, mostly related to infections, seizures or stimulation-induced side effects. We report a case of a 71-year-old man with a 10-year history of PD who underwent bilateral placement of subthalamic nucleus DBS. As a complication, the patient showed subjective postoperative cognitive decline, and subsequent MRI showed peri-lead oedema, which progressed to large cystic cavitation around the leads without indication of infection. The patient received steroid therapy and the cavitations regressed without surgical intervention. |
| doi_str_mv | 10.1136/bcr-2015-211470 |
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Several clinical trials have indicated significant motor function improvement in patients undergoing subthalamic nucleus stimulation. This therapy is, rarely, associated with complications, mostly related to infections, seizures or stimulation-induced side effects. We report a case of a 71-year-old man with a 10-year history of PD who underwent bilateral placement of subthalamic nucleus DBS. As a complication, the patient showed subjective postoperative cognitive decline, and subsequent MRI showed peri-lead oedema, which progressed to large cystic cavitation around the leads without indication of infection. The patient received steroid therapy and the cavitations regressed without surgical intervention.</description><identifier>ISSN: 1757-790X</identifier><identifier>EISSN: 1757-790X</identifier><identifier>DOI: 10.1136/bcr-2015-211470</identifier><identifier>PMID: 26475878</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Aged ; Brain Diseases - etiology ; Brain Diseases - pathology ; Cavitation ; Cognition Disorders - etiology ; Cognitive ability ; Cysts ; Cysts - etiology ; Cysts - pathology ; Deep brain stimulation ; Deep Brain Stimulation - adverse effects ; Edema ; Edema - etiology ; Hemorrhage ; Humans ; Infections ; Male ; Medical imaging ; Movement disorders ; Neuropsychology ; Parkinson Disease - complications ; Parkinson Disease - therapy ; Parkinson's disease ; Steroids ; Surgery ; Surgical outcomes ; Unusual Presentation of More Common Disease/Injury ; USA/Canada ; White</subject><ispartof>BMJ case reports, 2015-10, Vol.2015, p.bcr2015211470</ispartof><rights>2015 BMJ Publishing Group Ltd</rights><rights>2015 BMJ Publishing Group Ltd.</rights><rights>Copyright: 2015 2015 BMJ Publishing Group Ltd</rights><rights>2015 BMJ Publishing Group Ltd 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b3710-e76687071908a22690d3da61ae561fc556dd3e7bdf24b0d2a4fff52388d752513</citedby><cites>FETCH-LOGICAL-b3710-e76687071908a22690d3da61ae561fc556dd3e7bdf24b0d2a4fff52388d752513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612520/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612520/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26475878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jagid, Jonathan</creatorcontrib><creatorcontrib>Madhavan, Karthik</creatorcontrib><creatorcontrib>Bregy, Amade</creatorcontrib><creatorcontrib>Desai, Mehul</creatorcontrib><creatorcontrib>Ruiz, Armando</creatorcontrib><creatorcontrib>Quencer, Robert</creatorcontrib><creatorcontrib>Landy, Howard J</creatorcontrib><title>Deep brain stimulation complicated by bilateral large cystic cavitation around the leads in a patient with Parkinson's disease</title><title>BMJ case reports</title><addtitle>BMJ Case Rep</addtitle><description>Deep brain stimulation (DBS) is an approved and effective therapy for patients suffering from advanced Parkinson's disease (PD). Several clinical trials have indicated significant motor function improvement in patients undergoing subthalamic nucleus stimulation. This therapy is, rarely, associated with complications, mostly related to infections, seizures or stimulation-induced side effects. We report a case of a 71-year-old man with a 10-year history of PD who underwent bilateral placement of subthalamic nucleus DBS. As a complication, the patient showed subjective postoperative cognitive decline, and subsequent MRI showed peri-lead oedema, which progressed to large cystic cavitation around the leads without indication of infection. 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Several clinical trials have indicated significant motor function improvement in patients undergoing subthalamic nucleus stimulation. This therapy is, rarely, associated with complications, mostly related to infections, seizures or stimulation-induced side effects. We report a case of a 71-year-old man with a 10-year history of PD who underwent bilateral placement of subthalamic nucleus DBS. As a complication, the patient showed subjective postoperative cognitive decline, and subsequent MRI showed peri-lead oedema, which progressed to large cystic cavitation around the leads without indication of infection. The patient received steroid therapy and the cavitations regressed without surgical intervention.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>26475878</pmid><doi>10.1136/bcr-2015-211470</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Brain Diseases - etiology Brain Diseases - pathology Cavitation Cognition Disorders - etiology Cognitive ability Cysts Cysts - etiology Cysts - pathology Deep brain stimulation Deep Brain Stimulation - adverse effects Edema Edema - etiology Hemorrhage Humans Infections Male Medical imaging Movement disorders Neuropsychology Parkinson Disease - complications Parkinson Disease - therapy Parkinson's disease Steroids Surgery Surgical outcomes Unusual Presentation of More Common Disease/Injury USA/Canada White |
| title | Deep brain stimulation complicated by bilateral large cystic cavitation around the leads in a patient with Parkinson's disease |
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