Measurement of the acute metabolic response to hypoxia in rat tumours in vivo using magnetic resonance spectroscopy and hyperpolarised pyruvate

Abstract Purpose To estimate the rate constant for pyruvate to lactate conversion in tumours in response to a hypoxic challenge, using hyperpolarised13 C1 -pyruvate and magnetic resonance spectroscopy. Methods and materials Hypoxic inspired gas was used to manipulate rat P22 fibrosarcoma oxygen tens...

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Veröffentlicht in:	Radiotherapy and oncology 2015-09, Vol.116 (3), p.392-399
Hauptverfasser:	Bluff, Joanne E, Reynolds, Steven, Metcalf, Stephen, Alizadeh, Tooba, Kazan, Samira M, Bucur, Adriana, Wholey, Emily G, Bibby, Becky A.S, Williams, Leigh, Paley, Martyn N, Tozer, Gillian M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbon Isotopes Disease Models, Animal Dynamic nuclear polarisation Fibrosarcoma - metabolism Hematology, Oncology and Palliative Medicine Hypoxia Hypoxia - metabolism Lactic Acid - metabolism Magnetic Resonance Spectroscopy Pyruvate metabolism Pyruvic Acid - metabolism Rats Tumour oxygenation
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