Allosteric interactions between receptor site 3 and 4 of voltage-gated sodium channels: a novel perspective for the underlying mechanism of scorpion sting-induced pain

BmK I, a site-3-specific modulator of voltage-gated sodium channels (VGSCs), causes pain and hyperalgesia in rats, while BmK IT2, a site-4-specific modulator of VGSCs, suppresses pain-related responses. A stronger pain-related effect has been previously attributed to Buthus martensi Karsch (BmK) ven...

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Veröffentlicht in:	The journal of venomous animals and toxins including tropical diseases 2015-10, Vol.21 (1), p.42-42, Article 42
Hauptverfasser:	Feng, Yi-Jun, Feng, Qi, Tao, Jie, Zhao, Rong, Ji, Yong-Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Health aspects Pain Physiological aspects Sodium Toxicity Toxins Venom
Online-Zugang:	Volltext
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