Expression of ECRG4, a novel esophageal cancer－related gene,downregulated by CpG island hypermethylation in human esophageal squamous cell carcinoma

AIM: To study the mechanisms responsible for inactivation of a novel esophageal cancer related gene 4 (ECRG4) in esophageal squamous cell carcinoma (ESCC).METHODS: A pair of primers was designed to amplify a 220 bD fragment, which contains 16 CpG sites in the core promoter region of the ECRG 4 gene....

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Veröffentlicht in:	World journal of gastroenterology : WJG 2003-06, Vol.9 (6), p.1174-1178
Hauptverfasser:	Yue, Chun-Mei, Deng, Da-Jun, Bi, Mei-Xia, Guo, Li-Ping, Lu, Shih-Hsin
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Squamous Cell - genetics CpG Islands - genetics DNA Methylation Down-Regulation ECRG4 Esophageal Cancer Esophageal Neoplasms - genetics Gene Expression Humans Neoplasm Proteins Proteins - genetics Tumor Cells, Cultured 基因表达 肿瘤病因学 食管癌
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