How labile is gastric infection with H pylori?
It is known that patients infected with H pylori can spontaneously become free from infection, and that the reverse change can occur. The time-scale of these conversions is expressed as percentages per year. Since they have been investigated in terms of serology, the changes are called sero-reversio...
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Veröffentlicht in: | World journal of gastroenterology : WJG 2007-09, Vol.13 (35), p.4665-4668 |
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description | It is known that patients infected with H pylori can spontaneously become free from infection, and that the reverse change can occur. The time-scale of these conversions is expressed as percentages per year. Since they have been investigated in terms of serology, the changes are called sero-reversion and sero-conversion respectively. Using serological evidence to investigate these phenomena is open to the criticisms that positive serology can be present in the absence of all other evidence of infection, and that a time-lag of 6-12 mo or longer can occur between eradication of the infection and sero-reversion. Investigations using direct evidence of current infection are sparse. The few that exist suggest that some individuals can seroconvert or sero-revert within six to twelve weeks. If these findings are confirmed, it means that some patients have an ability that is variable in time to resist, or spontaneously recover from, H pylori infection. Evidence suggests that the deciding factor of susceptibility is the level of gastric secretion of acid. |
doi_str_mv | 10.3748/wjg.v13.i35.4665 |
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The time-scale of these conversions is expressed as percentages per year. Since they have been investigated in terms of serology, the changes are called sero-reversion and sero-conversion respectively. Using serological evidence to investigate these phenomena is open to the criticisms that positive serology can be present in the absence of all other evidence of infection, and that a time-lag of 6-12 mo or longer can occur between eradication of the infection and sero-reversion. Investigations using direct evidence of current infection are sparse. The few that exist suggest that some individuals can seroconvert or sero-revert within six to twelve weeks. If these findings are confirmed, it means that some patients have an ability that is variable in time to resist, or spontaneously recover from, H pylori infection. Evidence suggests that the deciding factor of susceptibility is the level of gastric secretion of acid.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v13.i35.4665</identifier><identifier>PMID: 17729387</identifier><language>eng</language><publisher>United States: Departments of Surgery and Medical Microbiology, Royal Free and University College Medical School, United Kingdom</publisher><subject>Gastric Acid - metabolism ; Gastric Mucosa - metabolism ; Helicobacter Infections - pathology ; Helicobacter Infections - physiopathology ; Helicobacter pylori ; Humans ; Remission, Spontaneous ; Stomach - microbiology ; Stomach - pathology ; Stomach Diseases - microbiology ; Stomach Diseases - pathology ; Stomach Diseases - physiopathology ; Time Factors</subject><ispartof>World journal of gastroenterology : WJG, 2007-09, Vol.13 (35), p.4665-4668</ispartof><rights>Copyright © Wanfang Data Co. Ltd. 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All rights reserved. 2007</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-bdddcce1dec491e123903575beb938cb874cf4e46461f7a4dec0f43f0b34e07a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/wjg/wjg.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611187/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611187/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17729387$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hobsley, M</creatorcontrib><creatorcontrib>Tovey, F-I</creatorcontrib><creatorcontrib>Holton, J</creatorcontrib><title>How labile is gastric infection with H pylori?</title><title>World journal of gastroenterology : WJG</title><addtitle>World J Gastroenterol</addtitle><description>It is known that patients infected with H pylori can spontaneously become free from infection, and that the reverse change can occur. The time-scale of these conversions is expressed as percentages per year. Since they have been investigated in terms of serology, the changes are called sero-reversion and sero-conversion respectively. Using serological evidence to investigate these phenomena is open to the criticisms that positive serology can be present in the absence of all other evidence of infection, and that a time-lag of 6-12 mo or longer can occur between eradication of the infection and sero-reversion. Investigations using direct evidence of current infection are sparse. The few that exist suggest that some individuals can seroconvert or sero-revert within six to twelve weeks. If these findings are confirmed, it means that some patients have an ability that is variable in time to resist, or spontaneously recover from, H pylori infection. Evidence suggests that the deciding factor of susceptibility is the level of gastric secretion of acid.</description><subject>Gastric Acid - metabolism</subject><subject>Gastric Mucosa - metabolism</subject><subject>Helicobacter Infections - pathology</subject><subject>Helicobacter Infections - physiopathology</subject><subject>Helicobacter pylori</subject><subject>Humans</subject><subject>Remission, Spontaneous</subject><subject>Stomach - microbiology</subject><subject>Stomach - pathology</subject><subject>Stomach Diseases - microbiology</subject><subject>Stomach Diseases - pathology</subject><subject>Stomach Diseases - physiopathology</subject><subject>Time Factors</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkb1PwzAQxS0EoqWwM6EMiC3BX4mTBYQqoEiVWGC2HMduXaV2sZNG_e9x1YqP6YZ797u79wC4RjAjjJb3w2qRbRHJDMkzWhT5CRhjjKoUlxSegjGCkKUVwWwELkJYQYgJyfE5GCHGcEVKNgbZzA1JK2rTqsSEZCFC541MjNVKdsbZZDDdMpklm13rvHm8BGdatEFdHesEfL48f0xn6fz99W36NE8lKVGX1k3TSKlQoyStkEKYVJDkLK9VHdfKumRUaqpoQQukmaBRBzUlGtaEKsgEmYCHA3fT12vVSGU7L1q-8WYt_I47Yfj_jjVLvnBbHoEIlSwCbg-AQVgt7IKvXO9tPJlHz3D0heQQoii7O-7x7qtXoeNrE6RqW2GV6wMvSowKgmgUwoNQeheCV_rnFgT5Pos9l8cseMyC77OIIzd_f_gdOJpPvgEBz4Zr</recordid><startdate>20070921</startdate><enddate>20070921</enddate><creator>Hobsley, M</creator><creator>Tovey, F-I</creator><creator>Holton, J</creator><general>Departments of Surgery and Medical Microbiology, Royal Free and University College Medical School, United Kingdom</general><general>Baishideng Publishing Group Co., Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20070921</creationdate><title>How labile is gastric infection with H pylori?</title><author>Hobsley, M ; Tovey, F-I ; Holton, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-bdddcce1dec491e123903575beb938cb874cf4e46461f7a4dec0f43f0b34e07a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Gastric Acid - metabolism</topic><topic>Gastric Mucosa - metabolism</topic><topic>Helicobacter Infections - pathology</topic><topic>Helicobacter Infections - physiopathology</topic><topic>Helicobacter pylori</topic><topic>Humans</topic><topic>Remission, Spontaneous</topic><topic>Stomach - microbiology</topic><topic>Stomach - pathology</topic><topic>Stomach Diseases - microbiology</topic><topic>Stomach Diseases - pathology</topic><topic>Stomach Diseases - physiopathology</topic><topic>Time Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Hobsley, M</creatorcontrib><creatorcontrib>Tovey, F-I</creatorcontrib><creatorcontrib>Holton, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hobsley, M</au><au>Tovey, F-I</au><au>Holton, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>How labile is gastric infection with H pylori?</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World J Gastroenterol</addtitle><date>2007-09-21</date><risdate>2007</risdate><volume>13</volume><issue>35</issue><spage>4665</spage><epage>4668</epage><pages>4665-4668</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>It is known that patients infected with H pylori can spontaneously become free from infection, and that the reverse change can occur. The time-scale of these conversions is expressed as percentages per year. Since they have been investigated in terms of serology, the changes are called sero-reversion and sero-conversion respectively. Using serological evidence to investigate these phenomena is open to the criticisms that positive serology can be present in the absence of all other evidence of infection, and that a time-lag of 6-12 mo or longer can occur between eradication of the infection and sero-reversion. Investigations using direct evidence of current infection are sparse. The few that exist suggest that some individuals can seroconvert or sero-revert within six to twelve weeks. If these findings are confirmed, it means that some patients have an ability that is variable in time to resist, or spontaneously recover from, H pylori infection. 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subjects | Gastric Acid - metabolism Gastric Mucosa - metabolism Helicobacter Infections - pathology Helicobacter Infections - physiopathology Helicobacter pylori Humans Remission, Spontaneous Stomach - microbiology Stomach - pathology Stomach Diseases - microbiology Stomach Diseases - pathology Stomach Diseases - physiopathology Time Factors |
title | How labile is gastric infection with H pylori? |
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