Sex differences in MDMA-induced toxicity in Sprague-Dawley rats

Recent evidence demonstrates that female subjects show exaggerated responses to 3,4-methylenedioxymethamphetamine (MDMA) compared with males. The aim of our study was to evaluate sex differences and the role of endogenous gonadal hormones on the effects of MDMA. Fifty-six intact and gonadectomized m...

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Veröffentlicht in:	Functional neurology 2015-04, Vol.30 (2), p.131-137
Hauptverfasser:	Soleimani Asl, Sara, Mehdizadeh, Mehdi, Hamedi Shahraki, Soudabeh, Artimani, Tayebeh, Joghataei, Mohammad Taghi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bcl-2-Associated X Protein - metabolism Castration Female Hippocampus - metabolism Learning - drug effects Male Maze Learning - drug effects Memory - drug effects N-Methyl-3,4-methylenedioxyamphetamine - toxicity Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Rats, Sprague-Dawley Sex Characteristics
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