Targeting breast cancer with sugar-coated carbon nanotubes
To evaluate the use of glucosamine functionalized multiwalled carbon nanotubes (glyco-MWCNTs) for breast cancer targeting. Two types of glucosamine functionalized MWCNTs were developed (covalently linked glucosamine and non-covalently phospholipid-glucosamine coated) and evaluated for their potentia...
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| Veröffentlicht in: | Nanomedicine (London, England) England), 2015-08, Vol.10 (16), p.1-18 |
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| creator | Fahrenholtz, Cale D Hadimani, Mallinath King, S Bruce Torti, Suzy V Singh, Ravi |
| description | To evaluate the use of glucosamine functionalized multiwalled carbon nanotubes (glyco-MWCNTs) for breast cancer targeting.
Two types of glucosamine functionalized MWCNTs were developed (covalently linked glucosamine and non-covalently phospholipid-glucosamine coated) and evaluated for their potential to bind and target breast cancer cells
and
.
Binding of glyco-MWCNTs in breast cancer cells is mediated by specific interaction with glucose transporters. Glyco-MWCNTs prepared by non-covalent coating with phospholipid-glucosamine displayed an extended blood circulation time, delayed urinary clearance, low tissue retention and increased breast cancer tumor accumulation
. These studies lay the foundation for development of a cancer diagnostic agent based upon glyco-MWCNTs with the potential for superior accuracy over current radiopharmaceuticals. |
| doi_str_mv | 10.2217/NNM.15.90 |
| format | Article |
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Two types of glucosamine functionalized MWCNTs were developed (covalently linked glucosamine and non-covalently phospholipid-glucosamine coated) and evaluated for their potential to bind and target breast cancer cells
and
.
Binding of glyco-MWCNTs in breast cancer cells is mediated by specific interaction with glucose transporters. Glyco-MWCNTs prepared by non-covalent coating with phospholipid-glucosamine displayed an extended blood circulation time, delayed urinary clearance, low tissue retention and increased breast cancer tumor accumulation
. These studies lay the foundation for development of a cancer diagnostic agent based upon glyco-MWCNTs with the potential for superior accuracy over current radiopharmaceuticals.</description><identifier>ISSN: 1743-5889</identifier><identifier>EISSN: 1748-6963</identifier><identifier>DOI: 10.2217/NNM.15.90</identifier><identifier>PMID: 26296098</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Animals ; biocompatibility ; Breast cancer ; Carbohydrates - chemistry ; Cell Line, Tumor ; Diagnosis ; Health aspects ; imaging ; Mammary Neoplasms, Experimental - metabolism ; Mammary Neoplasms, Experimental - pathology ; metabolism ; Mice ; nanoparticle ; Nanotubes ; Nanotubes, Carbon ; self-assembly ; Tissue Distribution</subject><ispartof>Nanomedicine (London, England), 2015-08, Vol.10 (16), p.1-18</ispartof><rights>Future Medicine Ltd</rights><rights>COPYRIGHT 2015 Future Medicine Ltd.</rights><rights>2015 Future Medicine Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c549t-878c75cc2bf0d089b8b767ef7e8206d2de311376d0c524d410b7402c6d94ea9e3</citedby><cites>FETCH-LOGICAL-c549t-878c75cc2bf0d089b8b767ef7e8206d2de311376d0c524d410b7402c6d94ea9e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610120/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610120/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26296098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fahrenholtz, Cale D</creatorcontrib><creatorcontrib>Hadimani, Mallinath</creatorcontrib><creatorcontrib>King, S Bruce</creatorcontrib><creatorcontrib>Torti, Suzy V</creatorcontrib><creatorcontrib>Singh, Ravi</creatorcontrib><title>Targeting breast cancer with sugar-coated carbon nanotubes</title><title>Nanomedicine (London, England)</title><addtitle>Nanomedicine (Lond)</addtitle><description>To evaluate the use of glucosamine functionalized multiwalled carbon nanotubes (glyco-MWCNTs) for breast cancer targeting.
Two types of glucosamine functionalized MWCNTs were developed (covalently linked glucosamine and non-covalently phospholipid-glucosamine coated) and evaluated for their potential to bind and target breast cancer cells
and
.
Binding of glyco-MWCNTs in breast cancer cells is mediated by specific interaction with glucose transporters. Glyco-MWCNTs prepared by non-covalent coating with phospholipid-glucosamine displayed an extended blood circulation time, delayed urinary clearance, low tissue retention and increased breast cancer tumor accumulation
. These studies lay the foundation for development of a cancer diagnostic agent based upon glyco-MWCNTs with the potential for superior accuracy over current radiopharmaceuticals.</description><subject>Animals</subject><subject>biocompatibility</subject><subject>Breast cancer</subject><subject>Carbohydrates - chemistry</subject><subject>Cell Line, Tumor</subject><subject>Diagnosis</subject><subject>Health aspects</subject><subject>imaging</subject><subject>Mammary Neoplasms, Experimental - metabolism</subject><subject>Mammary Neoplasms, Experimental - pathology</subject><subject>metabolism</subject><subject>Mice</subject><subject>nanoparticle</subject><subject>Nanotubes</subject><subject>Nanotubes, Carbon</subject><subject>self-assembly</subject><subject>Tissue Distribution</subject><issn>1743-5889</issn><issn>1748-6963</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkk1v1DAQhi0EoqVw4A-gSFzgkMV2_MkBqar4kkq5lLPlOJPUVWIX2wH139fLLgtFyAd7PM-845kxQs8J3lBK5JuLiy8bwjcaP0DHRDLVCi26h7_OXcuV0kfoSc7XGHNFCX6MjqigWmCtjtHbS5smKD5MTZ_A5tI4Gxyk5qcvV01eJ5taF22BoTpSH0MTbIhl7SE_RY9GO2d4tt9P0LcP7y_PPrXnXz9-Pjs9bx1nurRKKie5c7Qf8YCV7lUvhYRRgqJYDHSAjpBOigE7TtnACO4lw9SJQTOwGroT9G6ne7P2CwwOQkl2NjfJLzbdmmi9ue8J_spM8YdhgmBCcRV4tRdI8fsKuZjFZwfzbAPENRuimKhpCdcVffkPeh3XFGp5hkgsOWFa4T_UZGcwPoyx5nVbUXPKqJC8NlpVavMfqq4BFu9igNHX-3sBr3cBLsWcE4yHGgk220GbEBZDuNHbJ7z4uykH8vdkK8B3wLiWNUF2Hupczc6qEd75AAfh-oP2wnf91rQD</recordid><startdate>20150801</startdate><enddate>20150801</enddate><creator>Fahrenholtz, Cale D</creator><creator>Hadimani, Mallinath</creator><creator>King, S Bruce</creator><creator>Torti, Suzy V</creator><creator>Singh, Ravi</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20150801</creationdate><title>Targeting breast cancer with sugar-coated carbon nanotubes</title><author>Fahrenholtz, Cale D ; Hadimani, Mallinath ; King, S Bruce ; Torti, Suzy V ; Singh, Ravi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c549t-878c75cc2bf0d089b8b767ef7e8206d2de311376d0c524d410b7402c6d94ea9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>biocompatibility</topic><topic>Breast cancer</topic><topic>Carbohydrates - chemistry</topic><topic>Cell Line, Tumor</topic><topic>Diagnosis</topic><topic>Health aspects</topic><topic>imaging</topic><topic>Mammary Neoplasms, Experimental - metabolism</topic><topic>Mammary Neoplasms, Experimental - pathology</topic><topic>metabolism</topic><topic>Mice</topic><topic>nanoparticle</topic><topic>Nanotubes</topic><topic>Nanotubes, Carbon</topic><topic>self-assembly</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fahrenholtz, Cale D</creatorcontrib><creatorcontrib>Hadimani, Mallinath</creatorcontrib><creatorcontrib>King, S Bruce</creatorcontrib><creatorcontrib>Torti, Suzy V</creatorcontrib><creatorcontrib>Singh, Ravi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nanomedicine (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fahrenholtz, Cale D</au><au>Hadimani, Mallinath</au><au>King, S Bruce</au><au>Torti, Suzy V</au><au>Singh, Ravi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Targeting breast cancer with sugar-coated carbon nanotubes</atitle><jtitle>Nanomedicine (London, England)</jtitle><addtitle>Nanomedicine (Lond)</addtitle><date>2015-08-01</date><risdate>2015</risdate><volume>10</volume><issue>16</issue><spage>1</spage><epage>18</epage><pages>1-18</pages><issn>1743-5889</issn><eissn>1748-6963</eissn><abstract>To evaluate the use of glucosamine functionalized multiwalled carbon nanotubes (glyco-MWCNTs) for breast cancer targeting.
Two types of glucosamine functionalized MWCNTs were developed (covalently linked glucosamine and non-covalently phospholipid-glucosamine coated) and evaluated for their potential to bind and target breast cancer cells
and
.
Binding of glyco-MWCNTs in breast cancer cells is mediated by specific interaction with glucose transporters. Glyco-MWCNTs prepared by non-covalent coating with phospholipid-glucosamine displayed an extended blood circulation time, delayed urinary clearance, low tissue retention and increased breast cancer tumor accumulation
. These studies lay the foundation for development of a cancer diagnostic agent based upon glyco-MWCNTs with the potential for superior accuracy over current radiopharmaceuticals.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>26296098</pmid><doi>10.2217/NNM.15.90</doi><tpages>18</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals biocompatibility Breast cancer Carbohydrates - chemistry Cell Line, Tumor Diagnosis Health aspects imaging Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - pathology metabolism Mice nanoparticle Nanotubes Nanotubes, Carbon self-assembly Tissue Distribution |
| title | Targeting breast cancer with sugar-coated carbon nanotubes |
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