Antitumor Efficacy and Mechanism in Hepatoma H22-Bearing Mice of Brucea javanica Oil
Brucea javanica is a traditional herbal medicine in China, and its antitumor activities are of research interest. Brucea javanica oil, extracted with ether and refined with 10% ethyl alcohol from Brucea javanica seed, was used to treat hepatoma H22-bearing mice in this study. The antitumor effect an...
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| creator | Cai, Xue-Rong Huang, Qiong-Ying Wang, Xiao-Ting Liu, Yan Shi, Wen-Rong Wu, Shao-Rong |
| description | Brucea javanica is a traditional herbal medicine in China, and its antitumor activities are of research interest. Brucea javanica oil, extracted with ether and refined with 10% ethyl alcohol from Brucea javanica seed, was used to treat hepatoma H22-bearing mice in this study. The antitumor effect and probable mechanisms of the extracted Brucea javanica oil were studied in H22-bearing mice by WBC count, GOT, GPT levels, and western blotting. The H22 tumor inhibition ratio of 0.5, 1, and 1.5 g/kg bw Brucea javanica oil were 15.64%, 23.87%, and 38.27%. Brucea javanica oil could inhibit the involution of thymus induced by H22 tumor-bearing, but it could not inhibit the augmentation of spleen and liver. Brucea javanica oil could decrease the levels of WBC count and GOT and GPT in H22-bearing mice. The protein levels of GAPDH, Akt, TGF-β1, and α-SMA in tumor tissues decreased after being treated with Brucea javanica oil. Disturbing energy metabolism and neoplastic hyperplasia controlled by Akt and immunoregulation activity were its probable antitumor mechanisms in hepatoma H22-bearing mice. |
| doi_str_mv | 10.1155/2015/217494 |
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Brucea javanica oil, extracted with ether and refined with 10% ethyl alcohol from Brucea javanica seed, was used to treat hepatoma H22-bearing mice in this study. The antitumor effect and probable mechanisms of the extracted Brucea javanica oil were studied in H22-bearing mice by WBC count, GOT, GPT levels, and western blotting. The H22 tumor inhibition ratio of 0.5, 1, and 1.5 g/kg bw Brucea javanica oil were 15.64%, 23.87%, and 38.27%. Brucea javanica oil could inhibit the involution of thymus induced by H22 tumor-bearing, but it could not inhibit the augmentation of spleen and liver. Brucea javanica oil could decrease the levels of WBC count and GOT and GPT in H22-bearing mice. The protein levels of GAPDH, Akt, TGF-β1, and α-SMA in tumor tissues decreased after being treated with Brucea javanica oil. Disturbing energy metabolism and neoplastic hyperplasia controlled by Akt and immunoregulation activity were its probable antitumor mechanisms in hepatoma H22-bearing mice.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2015/217494</identifier><identifier>PMID: 26508976</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Apoptosis ; Cancer ; Chinese medicine ; Collaboration ; Hepatoma ; Hypoxia ; Immunoglobulins ; Laboratory animals ; Liver ; Medical research ; Medicine, Botanic ; Medicine, Herbal ; Metabolism ; Metastasis ; Seeds ; Transforming growth factors ; Tumors ; Vegetable oils</subject><ispartof>Evidence-based complementary and alternative medicine, 2015-01, Vol.2015 (2015), p.1-8</ispartof><rights>Copyright © 2015 Wen-Rong Shi et al.</rights><rights>COPYRIGHT 2015 John Wiley & Sons, Inc.</rights><rights>Copyright © 2015 Wen-Rong Shi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2015 Wen-Rong Shi et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-97b9b3b1efc5e72d56ca86e749484aa3363fdf6077dde04c8ba116f69f9be3463</citedby><cites>FETCH-LOGICAL-c458t-97b9b3b1efc5e72d56ca86e749484aa3363fdf6077dde04c8ba116f69f9be3463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609869/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609869/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26508976$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hawk, Cheryl</contributor><creatorcontrib>Cai, Xue-Rong</creatorcontrib><creatorcontrib>Huang, Qiong-Ying</creatorcontrib><creatorcontrib>Wang, Xiao-Ting</creatorcontrib><creatorcontrib>Liu, Yan</creatorcontrib><creatorcontrib>Shi, Wen-Rong</creatorcontrib><creatorcontrib>Wu, Shao-Rong</creatorcontrib><title>Antitumor Efficacy and Mechanism in Hepatoma H22-Bearing Mice of Brucea javanica Oil</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Brucea javanica is a traditional herbal medicine in China, and its antitumor activities are of research interest. Brucea javanica oil, extracted with ether and refined with 10% ethyl alcohol from Brucea javanica seed, was used to treat hepatoma H22-bearing mice in this study. The antitumor effect and probable mechanisms of the extracted Brucea javanica oil were studied in H22-bearing mice by WBC count, GOT, GPT levels, and western blotting. The H22 tumor inhibition ratio of 0.5, 1, and 1.5 g/kg bw Brucea javanica oil were 15.64%, 23.87%, and 38.27%. Brucea javanica oil could inhibit the involution of thymus induced by H22 tumor-bearing, but it could not inhibit the augmentation of spleen and liver. Brucea javanica oil could decrease the levels of WBC count and GOT and GPT in H22-bearing mice. The protein levels of GAPDH, Akt, TGF-β1, and α-SMA in tumor tissues decreased after being treated with Brucea javanica oil. Disturbing energy metabolism and neoplastic hyperplasia controlled by Akt and immunoregulation activity were its probable antitumor mechanisms in hepatoma H22-bearing mice.</description><subject>Apoptosis</subject><subject>Cancer</subject><subject>Chinese medicine</subject><subject>Collaboration</subject><subject>Hepatoma</subject><subject>Hypoxia</subject><subject>Immunoglobulins</subject><subject>Laboratory animals</subject><subject>Liver</subject><subject>Medical research</subject><subject>Medicine, Botanic</subject><subject>Medicine, Herbal</subject><subject>Metabolism</subject><subject>Metastasis</subject><subject>Seeds</subject><subject>Transforming growth factors</subject><subject>Tumors</subject><subject>Vegetable oils</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0c1rFDEYBvBBFPuhJ-8S8CLK6iSZfF0K29K6QksvFbyFdzJvdrPMZNbMTKX_vRm2rtWTlySQH0_y8BbFG1p-olSIz6ykeaGqMtWz4jjvdFExrZ8fzur7UXEyDNuyZEYp9bI4YlKU2ih5XNwt4xjGqesTufQ-OHAPBGJDbtBtIIahIyGSFe5g7DsgK8YW5wgpxDW5CQ5J78l5mhwC2cJ99g7IbWhfFS88tAO-ftxPi29Xl3cXq8X17ZevF8vrhauEHhdG1abmNUXvBCrWCOlAS5yL6AqAc8l942WpVNNgWTldA6XSS-NNjbyS_LQ42-fuprrDxmEcE7R2l0IH6cH2EOzfNzFs7Lq_t5UsjZYmB7x_DEj9jwmH0XZhcNi2ELGfBksV00xobmim7_6h235KMdebFdOCG2b-qDW0aEP0fX7XzaF2mTvLSjDDsvq4Vy71w5DQH75MSzvP1M4ztfuZZv32acuD_T3EDD7swSbEBn6G_0vDTNDDEywpE5z_AlxVsNI</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Cai, Xue-Rong</creator><creator>Huang, Qiong-Ying</creator><creator>Wang, Xiao-Ting</creator><creator>Liu, Yan</creator><creator>Shi, Wen-Rong</creator><creator>Wu, Shao-Rong</creator><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150101</creationdate><title>Antitumor Efficacy and Mechanism in Hepatoma H22-Bearing Mice of Brucea javanica Oil</title><author>Cai, Xue-Rong ; 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Brucea javanica oil, extracted with ether and refined with 10% ethyl alcohol from Brucea javanica seed, was used to treat hepatoma H22-bearing mice in this study. The antitumor effect and probable mechanisms of the extracted Brucea javanica oil were studied in H22-bearing mice by WBC count, GOT, GPT levels, and western blotting. The H22 tumor inhibition ratio of 0.5, 1, and 1.5 g/kg bw Brucea javanica oil were 15.64%, 23.87%, and 38.27%. Brucea javanica oil could inhibit the involution of thymus induced by H22 tumor-bearing, but it could not inhibit the augmentation of spleen and liver. Brucea javanica oil could decrease the levels of WBC count and GOT and GPT in H22-bearing mice. The protein levels of GAPDH, Akt, TGF-β1, and α-SMA in tumor tissues decreased after being treated with Brucea javanica oil. Disturbing energy metabolism and neoplastic hyperplasia controlled by Akt and immunoregulation activity were its probable antitumor mechanisms in hepatoma H22-bearing mice.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>26508976</pmid><doi>10.1155/2015/217494</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Apoptosis Cancer Chinese medicine Collaboration Hepatoma Hypoxia Immunoglobulins Laboratory animals Liver Medical research Medicine, Botanic Medicine, Herbal Metabolism Metastasis Seeds Transforming growth factors Tumors Vegetable oils |
| title | Antitumor Efficacy and Mechanism in Hepatoma H22-Bearing Mice of Brucea javanica Oil |
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