Angiotensinase C mRNA and Protein Downregulations Are Involved in Ethanol-Deteriorated Left Ventricular Systolic Dysfunction in Spontaneously Hypertensive Rats

The influences of angiotensinase C on ethanol-induced left ventricular (LV) systolic function were assessed in spontaneously hypertensive rats (SHRs). SHRs were fed by a liquid diet with or without ethanol for 49 days. The normotensive Wistar Kyoto rats (WKY) were fed by the liquid diet without etha...

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Veröffentlicht in:	BioMed research international 2015-01, Vol.2015 (2015), p.1-10
Hauptverfasser:	Liu, Jinyao, Fujimiya, Tatsuya, Hakucho, Ayako
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Animals Arterial Pressure Biomedical research Blood Pressure Carboxypeptidases - metabolism Collagen Type III - metabolism Disease Models, Animal Ethanol Ethanol - chemistry Gene Expression Regulation Genetic aspects Health aspects Heart attacks Heart Rate Heart Ventricles Hypertension Male Matrix Metalloproteinase 9 - metabolism Messenger RNA Methods Myocardium - pathology Rats Rats, Inbred SHR Rats, Inbred WKY Real-Time Polymerase Chain Reaction Receptor, Angiotensin, Type 1 - metabolism Renin-Angiotensin System RNA sequencing RNA, Messenger - metabolism Rodents Studies Systole - drug effects Ventricular Dysfunction, Left - chemically induced Ventricular Dysfunction, Left - metabolism
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