Clinical Applications of S53P4 Bioactive Glass in Bone Healing and Osteomyelitic Treatment: A Literature Review

Nowadays, S53P4 bioactive glass is indicated as a bone graft substitute in various clinical applications. This review provides an overview of the current published clinical results on indications such as craniofacial procedures, grafting of benign bone tumour defects, instrumental spondylodesis, and...

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Veröffentlicht in:BioMed research international 2015-01, Vol.2015 (2015), p.1-12
Hauptverfasser: Hofmann, S., van Rietbergen, B., Hulsen, D. J. W., Geurts, J., van Gestel, N. A. P., Arts, Jacobus J. C.
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container_issue 2015
container_start_page 1
container_title BioMed research international
container_volume 2015
creator Hofmann, S.
van Rietbergen, B.
Hulsen, D. J. W.
Geurts, J.
van Gestel, N. A. P.
Arts, Jacobus J. C.
description Nowadays, S53P4 bioactive glass is indicated as a bone graft substitute in various clinical applications. This review provides an overview of the current published clinical results on indications such as craniofacial procedures, grafting of benign bone tumour defects, instrumental spondylodesis, and the treatment of osteomyelitis. Given the reported results that are based on examinations, such as clinical examinations by the surgeons, radiographs, CT, and MRI images, S53P4 bioactive glass may be beneficial in the various reported applications. Especially in craniofacial reconstructions like mastoid obliteration and orbital floor reconstructions, in grafting bone tumour defects, and in the treatment of osteomyelitis very promising results are obtained. Randomized clinical trials need to be performed in order to determine whether bioactive glass would be able to replace the current golden standard of autologous bone usage or with the use of antibiotic containing PMMA beads (in the case of osteomyelitis).
doi_str_mv 10.1155/2015/684826
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Especially in craniofacial reconstructions like mastoid obliteration and orbital floor reconstructions, in grafting bone tumour defects, and in the treatment of osteomyelitis very promising results are obtained. Randomized clinical trials need to be performed in order to determine whether bioactive glass would be able to replace the current golden standard of autologous bone usage or with the use of antibiotic containing PMMA beads (in the case of osteomyelitis).</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2015/684826</identifier><identifier>PMID: 26504821</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Bone regeneration ; Bone Substitutes - chemistry ; Bone Substitutes - pharmacology ; Bone Substitutes - therapeutic use ; Care and treatment ; Fracture Healing - drug effects ; Glass ; Humans ; Literature reviews ; Methods ; Osteomyelitis ; Osteomyelitis - drug therapy ; Review</subject><ispartof>BioMed research international, 2015-01, Vol.2015 (2015), p.1-12</ispartof><rights>Copyright © 2015 N. A. 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subjects Bone regeneration
Bone Substitutes - chemistry
Bone Substitutes - pharmacology
Bone Substitutes - therapeutic use
Care and treatment
Fracture Healing - drug effects
Glass
Humans
Literature reviews
Methods
Osteomyelitis
Osteomyelitis - drug therapy
Review
title Clinical Applications of S53P4 Bioactive Glass in Bone Healing and Osteomyelitic Treatment: A Literature Review
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