Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

Eukaryotic cells possess numerous dynamic membrane-less organelles, RNP granules, enriched in RNA and RNA-binding proteins containing disordered regions. We demonstrate that the disordered regions of key RNP granule components and the full-length granule protein hnRNPA1 can phase separate in vitro,...

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Veröffentlicht in:	Molecular cell 2015-10, Vol.60 (2), p.208-219
Hauptverfasser:	Lin, Yuan, Protter, David S.W., Rosen, Michael K., Parker, Roy
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid - chemistry Amyloid - genetics Amyloid - metabolism Cytoplasmic Granules - chemistry Cytoplasmic Granules - metabolism Escherichia coli - genetics Escherichia coli - metabolism Fluorescence Recovery After Photobleaching Gene Expression Heterogeneous Nuclear Ribonucleoprotein A1 Heterogeneous-Nuclear Ribonucleoprotein Group A-B - chemistry Heterogeneous-Nuclear Ribonucleoprotein Group A-B - genetics Heterogeneous-Nuclear Ribonucleoprotein Group A-B - metabolism Humans Intrinsically Disordered Proteins - chemistry Intrinsically Disordered Proteins - genetics Intrinsically Disordered Proteins - metabolism Molecular Mimicry Organelles - chemistry Organelles - metabolism Polyethylene Glycols - chemistry Protein Aggregation, Pathological - genetics Protein Aggregation, Pathological - metabolism Protein Aggregation, Pathological - pathology Protein Binding Protein Structure, Tertiary Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism RNA - chemistry RNA - metabolism Sodium Chloride - chemistry Solutions
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