Lenalidomide Enhances Immune Checkpoint Blockade-Induced Immune Response in Multiple Myeloma

PD-1/PD-L1 signaling promotes tumor growth while inhibiting effector cell-mediated antitumor immune responses. Here, we assessed the impact of single and dual blockade of PD-1/PD-L1, alone or in combination with lenalidomide, on accessory and immune cell function as well as multiple myeloma cell gro...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical cancer research 2015-10, Vol.21 (20), p.4607-4618
Hauptverfasser:	Görgün, Güllü, Samur, Mehmet K, Cowens, Kristen B, Paula, Steven, Bianchi, Giada, Anderson, Julie E, White, Randie E, Singh, Ahaana, Ohguchi, Hiroto, Suzuki, Rikio, Kikuchi, Shohei, Harada, Takeshi, Hideshima, Teru, Tai, Yu-Tzu, Laubach, Jacob P, Raje, Noopur, Magrangeas, Florence, Minvielle, Stephane, Avet-Loiseau, Herve, Munshi, Nikhil C, Dorfman, David M, Richardson, Paul G, Anderson, Kenneth C
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - immunology Antigen-Presenting Cells - drug effects Antigen-Presenting Cells - immunology Antigen-Presenting Cells - metabolism B7-H1 Antigen - metabolism Bone Marrow - drug effects Bone Marrow - immunology Cancer Cell Line, Tumor Cell Proliferation - drug effects Humans Interferon-gamma - metabolism Life Sciences Multiple Myeloma - drug therapy Multiple Myeloma - immunology Programmed Cell Death 1 Receptor - metabolism RNA, Messenger - metabolism Signal Transduction - drug effects Signal Transduction - immunology Thalidomide - analogs & derivatives Thalidomide - pharmacology Tumor Microenvironment - drug effects Tumor Microenvironment - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!