A Ubl/ubiquitin switch in the activation of Parkin

Mutations in Parkin and PINK1 cause an inherited early‐onset form of Parkinson's disease. The two proteins function together in a mitochondrial quality control pathway whereby PINK1 accumulates on damaged mitochondria and activates Parkin to induce mitophagy. How PINK1 kinase activity releases...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The EMBO journal 2015-10, Vol.34 (20), p.2492-2505
Hauptverfasser:	Sauvé, Véronique, Lilov, Asparouh, Seirafi, Marjan, Vranas, Marta, Rasool, Shafqat, Kozlov, Guennadi, Sprules, Tara, Wang, Jimin, Trempe, Jean-François, Gehring, Kalle
Format:	Artikel
Sprache:	eng
Schlagworte:	Cloning, Molecular Crystallization EMBO24 EMBO31 EMBO40 Enzyme Activation - genetics Humans Kinases mitochondria Mitochondria - metabolism mitophagy Models, Molecular Mutagenesis Mutation Nuclear Magnetic Resonance, Biomolecular Parkinson's disease Phosphorylation Protein Binding Protein Conformation Protein Kinases - chemistry Protein Kinases - metabolism Protein Structure, Tertiary Proteins Quality control Scattering, Small Angle Ubiquitin - metabolism Ubiquitin-Conjugating Enzymes - metabolism Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - metabolism ubiquitination
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!