Genomic alterations in pancreatic cancer and their relevance to therapy

Genomic alterations in pancreatic cancer and their relevance to therapy

Pancreatic cancer is a highly lethal cancer type, for which there are few viable therapeutic options. But, with the advance of sequencing technologies for global genomic analysis, the landscape of genomic alterations in pancreatic cancer is becoming increasingly well understood. In this review, we s...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:World journal of gastrointestinal oncology 2015-10, Vol.7 (10), p.250-258
Hauptverfasser: Takai, Erina, Yachida, Shinichi
Format: Artikel
Sprache:eng
Schlagworte:
alterations
Signaling
cancer
Genomic
Pancreatic
Topic Highlight
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 258
container_issue 10
container_start_page 250
container_title World journal of gastrointestinal oncology
container_volume 7
creator Takai, Erina
Yachida, Shinichi
description Pancreatic cancer is a highly lethal cancer type, for which there are few viable therapeutic options. But, with the advance of sequencing technologies for global genomic analysis, the landscape of genomic alterations in pancreatic cancer is becoming increasingly well understood. In this review, we summarize current knowledge of genomic alterations in 12 core signaling pathways or cellular processes in pancreatic ductal adenocarcinoma, which is the most common type of malignancy in the pancreas, including four commonly mutated genes and many other genes that are mutated at low frequencies. We also describe the potential implications of these genomic alterations for development of novel therapeutic approaches in the context of personalized medicine.
doi_str_mv 10.4251/wjgo.v7.i10.250
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4606179</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>87747180504849534948484856</cqvip_id><sourcerecordid>1725024048</sourcerecordid><originalsourceid>FETCH-LOGICAL-c437t-98344353be142b7c2ed505649b8070341eb3627710360d0889694d63bdb51e1f3</originalsourceid><addsrcrecordid>eNpVUU1vGyEURFWrJnJ97q3aYy62YXl87CVSFLVuJUu9tGfEss821hocWDvKvw8ru5YLBx7DvHlohpCvjM6hFmzxutvE-UnNfQFqQT-Qe9aAnomawseb-o5Mc97RsgAUZfQzuaslaK5Vc0-WSwxx711l-wGTHXwMufKhOtjgEpa7q1wpMVU2dNWwRZ-qhD2eRrAa4ggle3j7Qj6tbZ9xejkn5O-P73-ef85Wv5e_np9WMwdcDbNGcwAueIsM6la5GjtBhYSm1VRRDgxbLmulGOWSdlTrRjbQSd52rWDI1nxCHs-6h2O7x85hGJLtzSH5vU1vJlpv_n8Jfms28WRAUslUUwQeLgIpvhwxD2bvs8O-twHjMRumipU10GLQhCzOVJdizgnX1zGMmjEBMyZgTsqUBExpKx3fbn935f_zuxD4RXIbw-bFh82Vo5UCxTQVZTQ0gkPJb9xC8nc7EZHV</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1725024048</pqid></control><display><type>article</type><title>Genomic alterations in pancreatic cancer and their relevance to therapy</title><source>Baishideng "World Journal of" online journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Takai, Erina ; Yachida, Shinichi</creator><creatorcontrib>Takai, Erina ; Yachida, Shinichi</creatorcontrib><description>Pancreatic cancer is a highly lethal cancer type, for which there are few viable therapeutic options. But, with the advance of sequencing technologies for global genomic analysis, the landscape of genomic alterations in pancreatic cancer is becoming increasingly well understood. In this review, we summarize current knowledge of genomic alterations in 12 core signaling pathways or cellular processes in pancreatic ductal adenocarcinoma, which is the most common type of malignancy in the pancreas, including four commonly mutated genes and many other genes that are mutated at low frequencies. We also describe the potential implications of these genomic alterations for development of novel therapeutic approaches in the context of personalized medicine.</description><identifier>ISSN: 1948-5204</identifier><identifier>EISSN: 1948-5204</identifier><identifier>DOI: 10.4251/wjgo.v7.i10.250</identifier><identifier>PMID: 26483879</identifier><language>eng</language><publisher>China: Baishideng Publishing Group Inc</publisher><subject>alterations;Signaling ; cancer;Genomic ; Pancreatic ; Topic Highlight</subject><ispartof>World journal of gastrointestinal oncology, 2015-10, Vol.7 (10), p.250-258</ispartof><rights>The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. 2015</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-98344353be142b7c2ed505649b8070341eb3627710360d0889694d63bdb51e1f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/71425X/71425X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606179/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606179/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26483879$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takai, Erina</creatorcontrib><creatorcontrib>Yachida, Shinichi</creatorcontrib><title>Genomic alterations in pancreatic cancer and their relevance to therapy</title><title>World journal of gastrointestinal oncology</title><addtitle>World Journal of Gastrointestinal Oncology</addtitle><description>Pancreatic cancer is a highly lethal cancer type, for which there are few viable therapeutic options. But, with the advance of sequencing technologies for global genomic analysis, the landscape of genomic alterations in pancreatic cancer is becoming increasingly well understood. In this review, we summarize current knowledge of genomic alterations in 12 core signaling pathways or cellular processes in pancreatic ductal adenocarcinoma, which is the most common type of malignancy in the pancreas, including four commonly mutated genes and many other genes that are mutated at low frequencies. We also describe the potential implications of these genomic alterations for development of novel therapeutic approaches in the context of personalized medicine.</description><subject>alterations;Signaling</subject><subject>cancer;Genomic</subject><subject>Pancreatic</subject><subject>Topic Highlight</subject><issn>1948-5204</issn><issn>1948-5204</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNpVUU1vGyEURFWrJnJ97q3aYy62YXl87CVSFLVuJUu9tGfEss821hocWDvKvw8ru5YLBx7DvHlohpCvjM6hFmzxutvE-UnNfQFqQT-Qe9aAnomawseb-o5Mc97RsgAUZfQzuaslaK5Vc0-WSwxx711l-wGTHXwMufKhOtjgEpa7q1wpMVU2dNWwRZ-qhD2eRrAa4ggle3j7Qj6tbZ9xejkn5O-P73-ef85Wv5e_np9WMwdcDbNGcwAueIsM6la5GjtBhYSm1VRRDgxbLmulGOWSdlTrRjbQSd52rWDI1nxCHs-6h2O7x85hGJLtzSH5vU1vJlpv_n8Jfms28WRAUslUUwQeLgIpvhwxD2bvs8O-twHjMRumipU10GLQhCzOVJdizgnX1zGMmjEBMyZgTsqUBExpKx3fbn935f_zuxD4RXIbw-bFh82Vo5UCxTQVZTQ0gkPJb9xC8nc7EZHV</recordid><startdate>20151015</startdate><enddate>20151015</enddate><creator>Takai, Erina</creator><creator>Yachida, Shinichi</creator><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151015</creationdate><title>Genomic alterations in pancreatic cancer and their relevance to therapy</title><author>Takai, Erina ; Yachida, Shinichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-98344353be142b7c2ed505649b8070341eb3627710360d0889694d63bdb51e1f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>alterations;Signaling</topic><topic>cancer;Genomic</topic><topic>Pancreatic</topic><topic>Topic Highlight</topic><toplevel>online_resources</toplevel><creatorcontrib>Takai, Erina</creatorcontrib><creatorcontrib>Yachida, Shinichi</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastrointestinal oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takai, Erina</au><au>Yachida, Shinichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genomic alterations in pancreatic cancer and their relevance to therapy</atitle><jtitle>World journal of gastrointestinal oncology</jtitle><addtitle>World Journal of Gastrointestinal Oncology</addtitle><date>2015-10-15</date><risdate>2015</risdate><volume>7</volume><issue>10</issue><spage>250</spage><epage>258</epage><pages>250-258</pages><issn>1948-5204</issn><eissn>1948-5204</eissn><abstract>Pancreatic cancer is a highly lethal cancer type, for which there are few viable therapeutic options. But, with the advance of sequencing technologies for global genomic analysis, the landscape of genomic alterations in pancreatic cancer is becoming increasingly well understood. In this review, we summarize current knowledge of genomic alterations in 12 core signaling pathways or cellular processes in pancreatic ductal adenocarcinoma, which is the most common type of malignancy in the pancreas, including four commonly mutated genes and many other genes that are mutated at low frequencies. We also describe the potential implications of these genomic alterations for development of novel therapeutic approaches in the context of personalized medicine.</abstract><cop>China</cop><pub>Baishideng Publishing Group Inc</pub><pmid>26483879</pmid><doi>10.4251/wjgo.v7.i10.250</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1948-5204
ispartof World journal of gastrointestinal oncology, 2015-10, Vol.7 (10), p.250-258
issn 1948-5204
1948-5204
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4606179
source Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects alterations
Signaling
cancer
Genomic
Pancreatic
Topic Highlight
title Genomic alterations in pancreatic cancer and their relevance to therapy
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T03%3A52%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genomic%20alterations%20in%20pancreatic%20cancer%20and%20their%20relevance%20to%20therapy&rft.jtitle=World%20journal%20of%20gastrointestinal%20oncology&rft.au=Takai,%20Erina&rft.date=2015-10-15&rft.volume=7&rft.issue=10&rft.spage=250&rft.epage=258&rft.pages=250-258&rft.issn=1948-5204&rft.eissn=1948-5204&rft_id=info:doi/10.4251/wjgo.v7.i10.250&rft_dat=%3Cproquest_pubme%3E1725024048%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1725024048&rft_id=info:pmid/26483879&rft_cqvip_id=87747180504849534948484856&rfr_iscdi=true