Immune cell interplay in colorectal cancer prognosis

Immune cell interplay in colorectal cancer prognosis

The immune response to colorectal cancer has proven to be a reliable measure of patient outcome in several studies. However, the complexity of the immune response in this disease is not well understood, par-ticularly the interactions between tumour-associated cells and cells of the innate and adapti...

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Veröffentlicht in:World journal of gastrointestinal oncology 2015-10, Vol.7 (10), p.221-232
Hauptverfasser: Norton, Samuel E, Ward-Hartstonge, Kirsten A, Taylor, Edward S, Kemp, Roslyn A
Format: Artikel
Sprache:eng
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cancer
Colorectal
neoplasms
Fibroblasts
Immune
sys
Topic Highlight
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container_end_page 232
container_issue 10
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container_title World journal of gastrointestinal oncology
container_volume 7
creator Norton, Samuel E
Ward-Hartstonge, Kirsten A
Taylor, Edward S
Kemp, Roslyn A
description The immune response to colorectal cancer has proven to be a reliable measure of patient outcome in several studies. However, the complexity of the immune response in this disease is not well understood, par-ticularly the interactions between tumour-associated cells and cells of the innate and adaptive immune system. This review will discuss the relationship betweencancer associated fibroblasts and macrophages, as well as between macrophages and T cells, and demonstrate how each population may support or prevent tumour growth in a different immune environment.
doi_str_mv 10.4251/wjgo.v7.i10.221
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source Baishideng "World Journal of" online journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central
subjects cancer
Colorectal
neoplasms
Fibroblasts
Immune
sys
Topic Highlight
title Immune cell interplay in colorectal cancer prognosis
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