Lung Function, Airway Inflammation, and Polycyclic Aromatic Hydrocarbons Exposure in Mexican Schoolchildren: A Pilot Study
OBJECTIVE:To determine the association of exposure to polycyclic aromatic hydrocarbons (PAHs) with lung function and pH of exhaled breath condensate (EBC) in Mexican schoolchildren. METHODS:A pilot study was performed in a subsample of 64 schoolchildren from Mexico City. Lung function and pH of EBC...
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| Veröffentlicht in: | Journal of occupational and environmental medicine 2014-04, Vol.56 (4), p.415-419 |
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| creator | Barraza-Villarreal, Albino Escamilla-Nuñez, Maria Consuelo Schilmann, Astrid Hernandez-Cadena, Leticia Li, Zheng Romanoff, Lovisa Sjödin, Andreas Del Río-Navarro, Blanca Estela Díaz-Sanchez, David Díaz-Barriga, Fernando Sly, Peter Romieu, Isabelle |
| description | OBJECTIVE:To determine the association of exposure to polycyclic aromatic hydrocarbons (PAHs) with lung function and pH of exhaled breath condensate (EBC) in Mexican schoolchildren.
METHODS:A pilot study was performed in a subsample of 64 schoolchildren from Mexico City. Lung function and pH of EBC were measured and metabolites of PAHs in urine samples were determined. The association was analyzed using robust regression models.
RESULTS:A 10% increase in the concentrations of 2-hydroxyfluorene was significantly negatively associated with forced expiratory volume in 1 second (−11.2 mL, 95% CI−22.2 to −0.02), forced vital capacity (−11.6 mL, 95% CI−22.9 to −0.2), and pH of EBC (−0.035, 95% CI−0.066 to −0.005).
CONCLUSION:Biomarkers of PAHs exposure were inversely associated with lung function and decrease of ph of EBC as a marker of airway inflammation in Mexican schoolchildren. |
| doi_str_mv | 10.1097/JOM.0000000000000111 |
| format | Article |
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METHODS:A pilot study was performed in a subsample of 64 schoolchildren from Mexico City. Lung function and pH of EBC were measured and metabolites of PAHs in urine samples were determined. The association was analyzed using robust regression models.
RESULTS:A 10% increase in the concentrations of 2-hydroxyfluorene was significantly negatively associated with forced expiratory volume in 1 second (−11.2 mL, 95% CI−22.2 to −0.02), forced vital capacity (−11.6 mL, 95% CI−22.9 to −0.2), and pH of EBC (−0.035, 95% CI−0.066 to −0.005).
CONCLUSION:Biomarkers of PAHs exposure were inversely associated with lung function and decrease of ph of EBC as a marker of airway inflammation in Mexican schoolchildren.</description><identifier>ISSN: 1076-2752</identifier><identifier>EISSN: 1536-5948</identifier><identifier>DOI: 10.1097/JOM.0000000000000111</identifier><identifier>PMID: 24500378</identifier><identifier>CODEN: JOEMFM</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, a business of Wolters Kluwer Health</publisher><subject>Adolescent ; Biological and medical sciences ; Biomarkers - urine ; Carcinogenesis, carcinogens and anticarcinogens ; Chemical agents ; Child ; Children & youth ; Cross-Sectional Studies ; Environmental Exposure - adverse effects ; Female ; Human exposure ; Humans ; Lungs ; Male ; Medical sciences ; Mexico - epidemiology ; Occupational health ; Original Article ; Pilot Projects ; Polycyclic aromatic hydrocarbons ; Polycyclic Aromatic Hydrocarbons - toxicity ; Polycyclic Aromatic Hydrocarbons - urine ; Regression analysis ; Respiratory Function Tests ; Risk Factors ; Surveys and Questionnaires ; Tumors</subject><ispartof>Journal of occupational and environmental medicine, 2014-04, Vol.56 (4), p.415-419</ispartof><rights>Copyright © 2014 by American College of Occupational and Environmental Medicine</rights><rights>Copyright © 2014 by the American College of Occupational and Environmental Medicine</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Lippincott Williams & Wilkins Apr 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4731-1ccb0d58b3be24e41bf8ce3cdb00c86f76df8ba0242d95c32e94d56ce5f8cb1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/48501151$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/48501151$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,803,885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28446850$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24500378$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barraza-Villarreal, Albino</creatorcontrib><creatorcontrib>Escamilla-Nuñez, Maria Consuelo</creatorcontrib><creatorcontrib>Schilmann, Astrid</creatorcontrib><creatorcontrib>Hernandez-Cadena, Leticia</creatorcontrib><creatorcontrib>Li, Zheng</creatorcontrib><creatorcontrib>Romanoff, Lovisa</creatorcontrib><creatorcontrib>Sjödin, Andreas</creatorcontrib><creatorcontrib>Del Río-Navarro, Blanca Estela</creatorcontrib><creatorcontrib>Díaz-Sanchez, David</creatorcontrib><creatorcontrib>Díaz-Barriga, Fernando</creatorcontrib><creatorcontrib>Sly, Peter</creatorcontrib><creatorcontrib>Romieu, Isabelle</creatorcontrib><title>Lung Function, Airway Inflammation, and Polycyclic Aromatic Hydrocarbons Exposure in Mexican Schoolchildren: A Pilot Study</title><title>Journal of occupational and environmental medicine</title><addtitle>J Occup Environ Med</addtitle><description>OBJECTIVE:To determine the association of exposure to polycyclic aromatic hydrocarbons (PAHs) with lung function and pH of exhaled breath condensate (EBC) in Mexican schoolchildren.
METHODS:A pilot study was performed in a subsample of 64 schoolchildren from Mexico City. Lung function and pH of EBC were measured and metabolites of PAHs in urine samples were determined. The association was analyzed using robust regression models.
RESULTS:A 10% increase in the concentrations of 2-hydroxyfluorene was significantly negatively associated with forced expiratory volume in 1 second (−11.2 mL, 95% CI−22.2 to −0.02), forced vital capacity (−11.6 mL, 95% CI−22.9 to −0.2), and pH of EBC (−0.035, 95% CI−0.066 to −0.005).
CONCLUSION:Biomarkers of PAHs exposure were inversely associated with lung function and decrease of ph of EBC as a marker of airway inflammation in Mexican schoolchildren.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - urine</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Chemical agents</subject><subject>Child</subject><subject>Children & youth</subject><subject>Cross-Sectional Studies</subject><subject>Environmental Exposure - adverse effects</subject><subject>Female</subject><subject>Human exposure</subject><subject>Humans</subject><subject>Lungs</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mexico - epidemiology</subject><subject>Occupational health</subject><subject>Original Article</subject><subject>Pilot Projects</subject><subject>Polycyclic aromatic hydrocarbons</subject><subject>Polycyclic Aromatic Hydrocarbons - toxicity</subject><subject>Polycyclic Aromatic Hydrocarbons - urine</subject><subject>Regression analysis</subject><subject>Respiratory Function Tests</subject><subject>Risk Factors</subject><subject>Surveys and Questionnaires</subject><subject>Tumors</subject><issn>1076-2752</issn><issn>1536-5948</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAUhCMEoqXwDwBZQkgcSLFjO3EuSKuqpUVbFQk4W86L03jrtbd2wjb_HldZltILvtjy-2b0RpNlrwk-JriuPn29ujzGDw8h5El2SDgtc14z8TS9cVXmRcWLg-xFjKuEcIL58-ygYBxjWonD7GY5umt0NjoYjHcf0cKErZrQheusWq_V_Klci755O8EE1gBaBH8_AXQ-tcGDCo13EZ3ebXwcg0bGoUt9Z0A59B167y30xrZBu5fZs07ZqF_t7qPs59npj5PzfHn15eJkscyBVZTkBKDBLRcNbXTBNCNNJ0BTaBuMQZRdVbadaBQuWNHWHGiha9byEjRPXEM0Pco-z76bsVnrFrQbgrJyE8xahUl6ZeS_E2d6ee1_SVZixus6GXzYGQR_O-o4yLWJoK1VTvsxSsIZw1hgXCX03SN05cfgUrxEEcGpqChNFJspCD7GoLv9MgTL-zZlalM-bjPJ3j4Mshf9qS8B73eAiqBsF5QDE_9ygrFScJw4MXNbbwcd4o0dtzrIXis79P_b4c0sXcXBh701S7YkJaS_Acn0xFI</recordid><startdate>201404</startdate><enddate>201404</enddate><creator>Barraza-Villarreal, Albino</creator><creator>Escamilla-Nuñez, Maria Consuelo</creator><creator>Schilmann, Astrid</creator><creator>Hernandez-Cadena, Leticia</creator><creator>Li, Zheng</creator><creator>Romanoff, Lovisa</creator><creator>Sjödin, Andreas</creator><creator>Del Río-Navarro, Blanca Estela</creator><creator>Díaz-Sanchez, David</creator><creator>Díaz-Barriga, Fernando</creator><creator>Sly, Peter</creator><creator>Romieu, Isabelle</creator><general>Lippincott Williams & Wilkins, a business of Wolters Kluwer Health</general><general>Copyright by the American College of Occupational and Environmental Medicine</general><general>Lippincott Williams & Wilkins</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7U2</scope><scope>5PM</scope></search><sort><creationdate>201404</creationdate><title>Lung Function, Airway Inflammation, and Polycyclic Aromatic Hydrocarbons Exposure in Mexican Schoolchildren</title><author>Barraza-Villarreal, Albino ; Escamilla-Nuñez, Maria Consuelo ; Schilmann, Astrid ; Hernandez-Cadena, Leticia ; Li, Zheng ; Romanoff, Lovisa ; Sjödin, Andreas ; Del Río-Navarro, Blanca Estela ; Díaz-Sanchez, David ; Díaz-Barriga, Fernando ; Sly, Peter ; Romieu, Isabelle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4731-1ccb0d58b3be24e41bf8ce3cdb00c86f76df8ba0242d95c32e94d56ce5f8cb1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - urine</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Chemical agents</topic><topic>Child</topic><topic>Children & youth</topic><topic>Cross-Sectional Studies</topic><topic>Environmental Exposure - adverse effects</topic><topic>Female</topic><topic>Human exposure</topic><topic>Humans</topic><topic>Lungs</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mexico - epidemiology</topic><topic>Occupational health</topic><topic>Original Article</topic><topic>Pilot Projects</topic><topic>Polycyclic aromatic hydrocarbons</topic><topic>Polycyclic Aromatic Hydrocarbons - toxicity</topic><topic>Polycyclic Aromatic Hydrocarbons - urine</topic><topic>Regression analysis</topic><topic>Respiratory Function Tests</topic><topic>Risk Factors</topic><topic>Surveys and Questionnaires</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barraza-Villarreal, Albino</creatorcontrib><creatorcontrib>Escamilla-Nuñez, Maria Consuelo</creatorcontrib><creatorcontrib>Schilmann, Astrid</creatorcontrib><creatorcontrib>Hernandez-Cadena, Leticia</creatorcontrib><creatorcontrib>Li, Zheng</creatorcontrib><creatorcontrib>Romanoff, Lovisa</creatorcontrib><creatorcontrib>Sjödin, Andreas</creatorcontrib><creatorcontrib>Del Río-Navarro, Blanca Estela</creatorcontrib><creatorcontrib>Díaz-Sanchez, David</creatorcontrib><creatorcontrib>Díaz-Barriga, Fernando</creatorcontrib><creatorcontrib>Sly, Peter</creatorcontrib><creatorcontrib>Romieu, Isabelle</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Safety Science and Risk</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of occupational and environmental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barraza-Villarreal, Albino</au><au>Escamilla-Nuñez, Maria Consuelo</au><au>Schilmann, Astrid</au><au>Hernandez-Cadena, Leticia</au><au>Li, Zheng</au><au>Romanoff, Lovisa</au><au>Sjödin, Andreas</au><au>Del Río-Navarro, Blanca Estela</au><au>Díaz-Sanchez, David</au><au>Díaz-Barriga, Fernando</au><au>Sly, Peter</au><au>Romieu, Isabelle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lung Function, Airway Inflammation, and Polycyclic Aromatic Hydrocarbons Exposure in Mexican Schoolchildren: A Pilot Study</atitle><jtitle>Journal of occupational and environmental medicine</jtitle><addtitle>J Occup Environ Med</addtitle><date>2014-04</date><risdate>2014</risdate><volume>56</volume><issue>4</issue><spage>415</spage><epage>419</epage><pages>415-419</pages><issn>1076-2752</issn><eissn>1536-5948</eissn><coden>JOEMFM</coden><abstract>OBJECTIVE:To determine the association of exposure to polycyclic aromatic hydrocarbons (PAHs) with lung function and pH of exhaled breath condensate (EBC) in Mexican schoolchildren.
METHODS:A pilot study was performed in a subsample of 64 schoolchildren from Mexico City. Lung function and pH of EBC were measured and metabolites of PAHs in urine samples were determined. The association was analyzed using robust regression models.
RESULTS:A 10% increase in the concentrations of 2-hydroxyfluorene was significantly negatively associated with forced expiratory volume in 1 second (−11.2 mL, 95% CI−22.2 to −0.02), forced vital capacity (−11.6 mL, 95% CI−22.9 to −0.2), and pH of EBC (−0.035, 95% CI−0.066 to −0.005).
CONCLUSION:Biomarkers of PAHs exposure were inversely associated with lung function and decrease of ph of EBC as a marker of airway inflammation in Mexican schoolchildren.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, a business of Wolters Kluwer Health</pub><pmid>24500378</pmid><doi>10.1097/JOM.0000000000000111</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Biological and medical sciences Biomarkers - urine Carcinogenesis, carcinogens and anticarcinogens Chemical agents Child Children & youth Cross-Sectional Studies Environmental Exposure - adverse effects Female Human exposure Humans Lungs Male Medical sciences Mexico - epidemiology Occupational health Original Article Pilot Projects Polycyclic aromatic hydrocarbons Polycyclic Aromatic Hydrocarbons - toxicity Polycyclic Aromatic Hydrocarbons - urine Regression analysis Respiratory Function Tests Risk Factors Surveys and Questionnaires Tumors |
| title | Lung Function, Airway Inflammation, and Polycyclic Aromatic Hydrocarbons Exposure in Mexican Schoolchildren: A Pilot Study |
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