Evidence for cooperative tandem binding of hnRNP C RRMs in mRNA processing

The human hnRNP C is a ubiquitous cellular protein involved in mRNA maturation. Recently, we have shown that this protein specifically recognizes uridine (U) pentamers through its single RNA recognition motif (RRM). However, a large fraction of natural RNA targets of hnRNP C consists of much longer...

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Veröffentlicht in:	RNA (Cambridge) 2015-11, Vol.21 (11), p.1931-1942
Hauptverfasser:	Cieniková, Zuzana, Jayne, Sandrine, Damberger, Fred Franz, Allain, Frédéric Hai-Trieu, Maris, Christophe
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites - genetics Heterogeneous-Nuclear Ribonucleoprotein Group C - metabolism Heterogeneous-Nuclear Ribonucleoproteins - genetics Humans Protein Binding - genetics RNA Recognition Motif Proteins - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Transcriptome - genetics Uridine - genetics Uridine - metabolism
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