Spontaneous early-onset glomerulonephritis in a 8-week-old male Crj:CD1 (ICR) mouse
Glomerular lesions including membranoproliferative glomerulonephritis occur spontaneously in aged mice, but they are rare in young animals. In our laboratory, spontaneous glomerulonephritis was observed in an 8-week-old male Crj:CD1 (ICR) mouse. Macroscopically, the bilateral kidneys were discolored...
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| Veröffentlicht in: | Journal of Toxicologic Pathology 2015, Vol.28(4), pp.237-241 |
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| creator | Ago, Kyohei Sugahara, Go Shirota, Kinji Kurata, Yasushi |
| description | Glomerular lesions including membranoproliferative glomerulonephritis occur spontaneously in aged mice, but they are rare in young animals. In our laboratory, spontaneous glomerulonephritis was observed in an 8-week-old male Crj:CD1 (ICR) mouse. Macroscopically, the bilateral kidneys were discolored, but no edema or ascites was observed. Glomerular lesions were characterized by a thickening of capillary walls, a double-contoured basement membrane and mesangial expansion due to increased amounts of matrix. Ultrastructurally, mesangial interposition in the capillary wall and subendothelial deposition of basement membrane-like material were observed. No evidence of immune complex deposition or amyloid was found. On the basis of the observed clinical pathology and histopathology, a secondary form of glomerular lesion was excluded. The glomerular lesion was compatible with glomerulonephritis in a young Crj:CD1 (ICR) mouse. |
| doi_str_mv | 10.1293/tox.2015-0015 |
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In our laboratory, spontaneous glomerulonephritis was observed in an 8-week-old male Crj:CD1 (ICR) mouse. Macroscopically, the bilateral kidneys were discolored, but no edema or ascites was observed. Glomerular lesions were characterized by a thickening of capillary walls, a double-contoured basement membrane and mesangial expansion due to increased amounts of matrix. Ultrastructurally, mesangial interposition in the capillary wall and subendothelial deposition of basement membrane-like material were observed. No evidence of immune complex deposition or amyloid was found. On the basis of the observed clinical pathology and histopathology, a secondary form of glomerular lesion was excluded. The glomerular lesion was compatible with glomerulonephritis in a young Crj:CD1 (ICR) mouse.</description><identifier>ISSN: 0914-9198</identifier><identifier>EISSN: 1881-915X</identifier><identifier>DOI: 10.1293/tox.2015-0015</identifier><identifier>PMID: 26538815</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY</publisher><subject>Case Report ; CD-1 ; glomerulonephritis ; kidney ; mouse ; spontaneous</subject><ispartof>Journal of Toxicologic Pathology, 2015, Vol.28(4), pp.237-241</ispartof><rights>2015 The Japanese Society of Toxicologic Pathology</rights><rights>2015 The Japanese Society of Toxicologic Pathology 2015</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5475-fc9542c0e47f06d6c3f671db02d6f1e458fde7941c7c57302cc57a4af430af173</citedby><cites>FETCH-LOGICAL-c5475-fc9542c0e47f06d6c3f671db02d6f1e458fde7941c7c57302cc57a4af430af173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604135/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604135/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1877,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26538815$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ago, Kyohei</creatorcontrib><creatorcontrib>Sugahara, Go</creatorcontrib><creatorcontrib>Shirota, Kinji</creatorcontrib><creatorcontrib>Kurata, Yasushi</creatorcontrib><title>Spontaneous early-onset glomerulonephritis in a 8-week-old male Crj:CD1 (ICR) mouse</title><title>Journal of Toxicologic Pathology</title><addtitle>J Toxicol Pathol</addtitle><description>Glomerular lesions including membranoproliferative glomerulonephritis occur spontaneously in aged mice, but they are rare in young animals. In our laboratory, spontaneous glomerulonephritis was observed in an 8-week-old male Crj:CD1 (ICR) mouse. Macroscopically, the bilateral kidneys were discolored, but no edema or ascites was observed. Glomerular lesions were characterized by a thickening of capillary walls, a double-contoured basement membrane and mesangial expansion due to increased amounts of matrix. Ultrastructurally, mesangial interposition in the capillary wall and subendothelial deposition of basement membrane-like material were observed. No evidence of immune complex deposition or amyloid was found. On the basis of the observed clinical pathology and histopathology, a secondary form of glomerular lesion was excluded. The glomerular lesion was compatible with glomerulonephritis in a young Crj:CD1 (ICR) mouse.</description><subject>Case Report</subject><subject>CD-1</subject><subject>glomerulonephritis</subject><subject>kidney</subject><subject>mouse</subject><subject>spontaneous</subject><issn>0914-9198</issn><issn>1881-915X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNpVkMtLxDAQh4Mo7vo4epUc9RBNmqQPD4LUJwiCD_AWsulkt2vbLEnXx39vltWil5mB-eYb-CF0wOgJSwp-2rvPk4QySWgsG2jM8pyRgsnXTTSmBRNxLvIR2glhTmmSUcm30ShJJY-cHKOnp4Xret2BWwYM2jdfxHUBejxtXAt-2bgOFjNf93XAdYc1zskHwBtxTYVb3QAu_fysvGT46K58PMZt1MAe2rK6CbD_03fRy_XVc3lL7h9u7sqLe2KkyCSxppAiMRREZmlapYbbNGPVhCZVahkImdsKskIwkxmZcZqY2LTQVnCqLcv4LjpfexfLSQuVga73ulELX7fafymna_V_09UzNXXvSqRUMC6jgKwFxrsQPNjhllG1SlfFdNUqXbVKN_KHfx8O9G-cESjXwDz0egoDoH1fmwbWulyJVRm0w9bMtFfQ8W88yY6Y</recordid><startdate>2015</startdate><enddate>2015</enddate><creator>Ago, Kyohei</creator><creator>Sugahara, Go</creator><creator>Shirota, Kinji</creator><creator>Kurata, Yasushi</creator><general>JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY</general><general>Japanese Society of Toxicologic Pathology</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>2015</creationdate><title>Spontaneous early-onset glomerulonephritis in a 8-week-old male Crj:CD1 (ICR) mouse</title><author>Ago, Kyohei ; Sugahara, Go ; Shirota, Kinji ; Kurata, Yasushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5475-fc9542c0e47f06d6c3f671db02d6f1e458fde7941c7c57302cc57a4af430af173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Case Report</topic><topic>CD-1</topic><topic>glomerulonephritis</topic><topic>kidney</topic><topic>mouse</topic><topic>spontaneous</topic><toplevel>online_resources</toplevel><creatorcontrib>Ago, Kyohei</creatorcontrib><creatorcontrib>Sugahara, Go</creatorcontrib><creatorcontrib>Shirota, Kinji</creatorcontrib><creatorcontrib>Kurata, Yasushi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Toxicologic Pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ago, Kyohei</au><au>Sugahara, Go</au><au>Shirota, Kinji</au><au>Kurata, Yasushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spontaneous early-onset glomerulonephritis in a 8-week-old male Crj:CD1 (ICR) mouse</atitle><jtitle>Journal of Toxicologic Pathology</jtitle><addtitle>J Toxicol Pathol</addtitle><date>2015</date><risdate>2015</risdate><volume>28</volume><issue>4</issue><spage>237</spage><epage>241</epage><pages>237-241</pages><issn>0914-9198</issn><eissn>1881-915X</eissn><abstract>Glomerular lesions including membranoproliferative glomerulonephritis occur spontaneously in aged mice, but they are rare in young animals. In our laboratory, spontaneous glomerulonephritis was observed in an 8-week-old male Crj:CD1 (ICR) mouse. Macroscopically, the bilateral kidneys were discolored, but no edema or ascites was observed. Glomerular lesions were characterized by a thickening of capillary walls, a double-contoured basement membrane and mesangial expansion due to increased amounts of matrix. Ultrastructurally, mesangial interposition in the capillary wall and subendothelial deposition of basement membrane-like material were observed. No evidence of immune complex deposition or amyloid was found. On the basis of the observed clinical pathology and histopathology, a secondary form of glomerular lesion was excluded. The glomerular lesion was compatible with glomerulonephritis in a young Crj:CD1 (ICR) mouse.</abstract><cop>Japan</cop><pub>JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY</pub><pmid>26538815</pmid><doi>10.1293/tox.2015-0015</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Case Report CD-1 glomerulonephritis kidney mouse spontaneous |
| title | Spontaneous early-onset glomerulonephritis in a 8-week-old male Crj:CD1 (ICR) mouse |
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