Matrix Gla protein regulates calcification of the aortic valve

Abstract Background The aortic valve interstitial cell (AVIC) has been implicated in the pathogenesis of aortic stenosis. In response to proinflammatory stimulation, the AVIC undergoes a phenotypic change from that of a myofibroblast phenotype to that of osteoblast-like cell. Matrix Gla-protein (MGP...

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Veröffentlicht in:	The Journal of surgical research 2015-11, Vol.199 (1), p.1-6
Hauptverfasser:	Venardos, Neil, MD, Bennett, Daine, MD, Weyant, Michael J., MD, Reece, Thomas Brett, MD, Meng, Xianzhong, MD, PhD, Fullerton, David A., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aortic stenosis Aortic Valve - metabolism Aortic Valve - pathology Aortic Valve Stenosis - metabolism Aortic Valve Stenosis - pathology Calcinosis - metabolism Calcinosis - pathology Calcium-Binding Proteins - metabolism Case-Control Studies Down-Regulation Enzyme-Linked Immunosorbent Assay Extracellular Matrix Proteins - metabolism Humans Immunoblotting Male Matrix Gla Protein Middle Aged Phenotype Reverse Transcriptase Polymerase Chain Reaction Surgery Valve interstitial cell
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