Synergistic Inhibitory Effects of Cetuximab and Cisplatin on Human Colon Cancer Cell Growth via Inhibition of the ERK-Dependent EGF Receptor Signaling Pathway

The purpose of this study was to evaluate the anticancer efficacy of cetuximab combined with cisplatin (combination treatment) on colon cancer growth, as well as its underlying action mechanism. Combination treatment synergistically potentiated the effect of cetuximab on cell growth inhibition and a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	BioMed research international 2015-01, Vol.2015 (2015), p.1-13
Hauptverfasser:	Han, Sang Bae, Hong, Jin Tae, Lee, Dong Won, Hwang, Jae Yeon, Gu, Sun Mi, Lee, Hye Lim, Park, Ju Ho, Ban, Jung Ok, Hong, Ji Eun, Son, Dong Ju, Jung, Myung Hee
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cancer cells Cancer therapies Cell growth Cell Line, Tumor Cellular signal transduction Cetuximab - pharmacology Chemotherapy Cisplatin Cisplatin - agonists Cisplatin - pharmacology Colon cancer Colonic Neoplasms - drug therapy Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colorectal cancer Complications and side effects Cytotoxicity Deoxyribonucleic acid Development and progression DNA Drug interactions Drug Synergism Epidermal growth factor Genetic aspects Growth Health aspects Humans MAP Kinase Signaling System - drug effects Observations Radiation therapy Receptor, Epidermal Growth Factor - metabolism Rodents Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!