TLR4 mutant mice are protected from renal fibrosis and chronic kidney disease progression

Chronic kidney disease (CKD) is associated with persistent low‐grade inflammation and immunosuppression. In this study we tested the role of Toll‐like receptor 4, the main receptor for endotoxin (LPS), in a mouse model of renal fibrosis and in a model of progressive CKD that better resembles the hum...

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Veröffentlicht in:	Physiological reports 2015-09, Vol.3 (9), p.e12558-n/a
Hauptverfasser:	Souza, Ana C. P., Tsuji, Takayuki, Baranova, Irina N., Bocharov, Alexander V., Wilkins, Kenneth J., Street, Jonathan M., Alvarez‐Prats, Alejandro, Hu, Xuzhen, Eggerman, Thomas, Yuen, Peter S. T., Star, Robert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Albuminuria endotoxemia inflammasome inflammation Original Research spleen apoptosis
Online-Zugang:	Volltext
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