Probing for a deeper understanding of rhabdomyosarcoma: insights from complementary model systems

Key Points Rhabdomyosarcoma (RMS) is a soft tissue malignancy composed of neoplastic cells that morphologically resemble skeletal muscle-lineage precursor cells. High-risk RMS has a dismal prognosis, and treatments for this condition have not improved for three decades now. RMS is a heterogeneous di...

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Veröffentlicht in:	Nature reviews. Cancer 2015-07, Vol.15 (7), p.426-439
Hauptverfasser:	Kashi, Venkatesh P., Hatley, Mark E., Galindo, Rene L.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/334/1582/715 631/1647/334/1874/345 631/1647/334/1874/763 631/67/1798 631/67/395 631/67/70 Animals Biomedicine Cancer Cancer Research Development and progression Disease Models, Animal Forkhead Box Protein O1 Forkhead Transcription Factors - genetics Genetic aspects Genetic research Genetic susceptibility Hedgehog Proteins - physiology Humans Mutation Myoblasts - metabolism Oncology, Experimental Paired Box Transcription Factors - genetics PAX3 Transcription Factor Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins p21(ras) ras Proteins - genetics review-article Rhabdomyosarcoma Rhabdomyosarcoma - etiology Rhabdomyosarcoma - genetics Rhabdomyosarcoma - therapy Stem Cells - metabolism
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