Goblet and Clara cells of human distal airways: evidence for smoking induced changes in their numbers
The goblet cell and Clara cell populations of human distal airway epithelium were examined. The bronchioles, terminal bronchioles, and respiratory bronchioles of 16 smokers and four non-smokers were studied by both light and electron microscopy in surgically resected specimens. A very significantly...
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| Veröffentlicht in: | Thorax 1984-11, Vol.39 (11), p.844-849 |
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| creator | Lumsden, A B McLean, A Lamb, D |
| description | The goblet cell and Clara cell populations of human distal airway epithelium were examined. The bronchioles, terminal bronchioles, and respiratory bronchioles of 16 smokers and four non-smokers were studied by both light and electron microscopy in surgically resected specimens. A very significantly (p less than 0.001) greater number of goblet cells were found in the bronchioles of smokers compared than in those of non-smokers but no such difference was evident in terminal/respiratory bronchioles. Clara cell numbers in contrast were lower in the bronchioles (p less than 0.01) and terminal and respiratory bronchioles of smokers (p less than 0.01). Both of these alterations in cell frequency may adversely affect small airway function in smokers. |
| doi_str_mv | 10.1136/thx.39.11.844 |
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The bronchioles, terminal bronchioles, and respiratory bronchioles of 16 smokers and four non-smokers were studied by both light and electron microscopy in surgically resected specimens. A very significantly (p less than 0.001) greater number of goblet cells were found in the bronchioles of smokers compared than in those of non-smokers but no such difference was evident in terminal/respiratory bronchioles. Clara cell numbers in contrast were lower in the bronchioles (p less than 0.01) and terminal and respiratory bronchioles of smokers (p less than 0.01). Both of these alterations in cell frequency may adversely affect small airway function in smokers.</description><identifier>ISSN: 0040-6376</identifier><identifier>EISSN: 1468-3296</identifier><identifier>DOI: 10.1136/thx.39.11.844</identifier><identifier>PMID: 6505991</identifier><identifier>CODEN: THORA7</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Thoracic Society</publisher><subject>Biological and medical sciences ; Bronchi - pathology ; Cell Count ; Epithelium - pathology ; Humans ; Medical sciences ; Mucous Membrane - pathology ; Smoking ; Tobacco, tobacco smoking ; Toxicology</subject><ispartof>Thorax, 1984-11, Vol.39 (11), p.844-849</ispartof><rights>1985 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Nov 1984</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b540t-9f21623746069c0a13aeb83bd28bf3f2bdf2d21bd63efb0e19edfc91ef4d50ba3</citedby><cites>FETCH-LOGICAL-b540t-9f21623746069c0a13aeb83bd28bf3f2bdf2d21bd63efb0e19edfc91ef4d50ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC459935/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC459935/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8914299$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6505991$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lumsden, A B</creatorcontrib><creatorcontrib>McLean, A</creatorcontrib><creatorcontrib>Lamb, D</creatorcontrib><title>Goblet and Clara cells of human distal airways: evidence for smoking induced changes in their numbers</title><title>Thorax</title><addtitle>Thorax</addtitle><description>The goblet cell and Clara cell populations of human distal airway epithelium were examined. The bronchioles, terminal bronchioles, and respiratory bronchioles of 16 smokers and four non-smokers were studied by both light and electron microscopy in surgically resected specimens. A very significantly (p less than 0.001) greater number of goblet cells were found in the bronchioles of smokers compared than in those of non-smokers but no such difference was evident in terminal/respiratory bronchioles. Clara cell numbers in contrast were lower in the bronchioles (p less than 0.01) and terminal and respiratory bronchioles of smokers (p less than 0.01). Both of these alterations in cell frequency may adversely affect small airway function in smokers.</description><subject>Biological and medical sciences</subject><subject>Bronchi - pathology</subject><subject>Cell Count</subject><subject>Epithelium - pathology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Mucous Membrane - pathology</subject><subject>Smoking</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><issn>0040-6376</issn><issn>1468-3296</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkc1v1DAQxSMEKkvhyBHJEghxyWLHjh1X4oBWUEBVufBxtOx4vPE2cYqdlPa_x6tdRcClJ4_1fmPPvFcUzwleE0L526m7XVOZ63XD2INiRRhvSlpJ_rBYYcxwyangj4snKe0wxg0h4qQ44TWupSSrAs5H08OEdLBo0-uoUQt9n9DoUDcPOiDr06R7pH38re_SGYIbbyG0gNwYURrGKx-2yAc7t2BR2-mwhZTvaOrARxTmwUBMT4tHTvcJnh3P0-L7xw_fNp_Ki6_nnzfvL0pTMzyV0lWEV1QwjrlssSZUg2mosVVjHHWVsa6yFTGWU3AGA5FgXSsJOGZrbDQ9Ld4d3r2ezQC2hTBF3avr6Acd79SovfpXCb5T2_FGsewGrXP_62N_HH_NkCY1-LQ3RAcY56RE3WDOKL0XJIxyIiXL4Mv_wN04x5BNUEQIQjGRtchUeaDaOKYUwS0jE6z2KaucsqIy1yqnnPkXf--50MdYs_7qqOvU6t5FHVqfFqyRhFV54eXbnDHcLrKOV4oLKmp1-WOjqp_ishHsi9rb8-bAm2F3z4R_ANklzXA</recordid><startdate>19841101</startdate><enddate>19841101</enddate><creator>Lumsden, A B</creator><creator>McLean, A</creator><creator>Lamb, D</creator><general>BMJ Publishing Group Ltd and British Thoracic Society</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19841101</creationdate><title>Goblet and Clara cells of human distal airways: evidence for smoking induced changes in their numbers</title><author>Lumsden, A B ; McLean, A ; Lamb, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b540t-9f21623746069c0a13aeb83bd28bf3f2bdf2d21bd63efb0e19edfc91ef4d50ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Biological and medical sciences</topic><topic>Bronchi - pathology</topic><topic>Cell Count</topic><topic>Epithelium - pathology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Mucous Membrane - pathology</topic><topic>Smoking</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lumsden, A B</creatorcontrib><creatorcontrib>McLean, A</creatorcontrib><creatorcontrib>Lamb, D</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Thorax</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lumsden, A B</au><au>McLean, A</au><au>Lamb, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Goblet and Clara cells of human distal airways: evidence for smoking induced changes in their numbers</atitle><jtitle>Thorax</jtitle><addtitle>Thorax</addtitle><date>1984-11-01</date><risdate>1984</risdate><volume>39</volume><issue>11</issue><spage>844</spage><epage>849</epage><pages>844-849</pages><issn>0040-6376</issn><eissn>1468-3296</eissn><coden>THORA7</coden><abstract>The goblet cell and Clara cell populations of human distal airway epithelium were examined. The bronchioles, terminal bronchioles, and respiratory bronchioles of 16 smokers and four non-smokers were studied by both light and electron microscopy in surgically resected specimens. A very significantly (p less than 0.001) greater number of goblet cells were found in the bronchioles of smokers compared than in those of non-smokers but no such difference was evident in terminal/respiratory bronchioles. Clara cell numbers in contrast were lower in the bronchioles (p less than 0.01) and terminal and respiratory bronchioles of smokers (p less than 0.01). Both of these alterations in cell frequency may adversely affect small airway function in smokers.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Thoracic Society</pub><pmid>6505991</pmid><doi>10.1136/thx.39.11.844</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences Bronchi - pathology Cell Count Epithelium - pathology Humans Medical sciences Mucous Membrane - pathology Smoking Tobacco, tobacco smoking Toxicology |
| title | Goblet and Clara cells of human distal airways: evidence for smoking induced changes in their numbers |
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