By recruiting HDAC1, MORC2 suppresses p21Waf1/Cip1 in gastric cancer

By recruiting HDAC1, MORC2 suppresses p21Waf1/Cip1 in gastric cancer

Microrchidia (MORC) family CW-type zinc-finger 2 (MORC2) regulates chromatin remodeling during the DNA-damage response, represses gene transcription, promotes lipogenesis. Here, we found that MORC2 down-regulated p21 by recruiting HDAC1 to the p21 promoter, in a p53-independent manner. MORC2-mediate...

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Veröffentlicht in:Oncotarget 2015-06, Vol.6 (18), p.16461-16470
Hauptverfasser: Zhang, Qing, Song, Yanyan, Chen, Wei, Wang, Xiaohui, Miao, Zhifeng, Cao, Liu, Li, Feng, Wang, Guiling
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container_end_page 16470
container_issue 18
container_start_page 16461
container_title Oncotarget
container_volume 6
creator Zhang, Qing
Song, Yanyan
Chen, Wei
Wang, Xiaohui
Miao, Zhifeng
Cao, Liu
Li, Feng
Wang, Guiling
description Microrchidia (MORC) family CW-type zinc-finger 2 (MORC2) regulates chromatin remodeling during the DNA-damage response, represses gene transcription, promotes lipogenesis. Here, we found that MORC2 down-regulated p21 by recruiting HDAC1 to the p21 promoter, in a p53-independent manner. MORC2-mediated down-regulation of p21 in turn promoted cell cycle progression in gastric cancer cells. Furthermore, MORC2 expression correlated negatively with p21 expression in gastric tumors in patients. We suggest that MORC2 may be a potential therapeutic target in cancer.
doi_str_mv 10.18632/oncotarget.3889
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title By recruiting HDAC1, MORC2 suppresses p21Waf1/Cip1 in gastric cancer
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