Accumulation of ALDH1-positive cells after neoadjuvant chemotherapy predicts treatment resistance and prognosticates poor outcome in ovarian cancer

Although ovarian cancer is a highly chemosensitive disease, it is only infrequently cured. One of the major reasons lies in the presence of drug-resistant cancer stem-like cells, sufficient to fuel recurrence. We phenotyped cancer stem-like cells by flow cytometry and immunohistochemistry in 55 matc...

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Veröffentlicht in:	Oncotarget 2015-06, Vol.6 (18), p.16437-16448
Hauptverfasser:	Ayub, Tiyasha H, Keyver-Paik, Mignon-Denise, Debald, Manuel, Rostamzadeh, Babak, Thiesler, Thore, Schröder, Lars, Barchet, Winfried, Abramian, Alina, Kaiser, Christina, Kristiansen, Glen, Kuhn, Walther, Kübler, Kirsten
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen Adult Aged Antigens, CD - metabolism Biomarkers, Tumor - metabolism Bridged-Ring Compounds - therapeutic use CD24 Antigen - metabolism Drug Resistance, Neoplasm Female Glycoproteins - metabolism Humans Isoenzymes - metabolism Middle Aged Neoadjuvant Therapy Neoplasm Recurrence, Local - pathology Neoplastic Stem Cells - pathology Ovarian Neoplasms - drug therapy Ovarian Neoplasms - pathology Peptides - metabolism Platinum Compounds - therapeutic use Proto-Oncogene Proteins c-kit - metabolism Research Paper Retinal Dehydrogenase - metabolism Retrospective Studies Taxoids - therapeutic use Treatment Outcome Tumor Stem Cell Assay
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