Loss of RAB1B promotes triple-negative breast cancer metastasis by activating TGF-β/SMAD signaling

Triple-negative breast cancer (TNBC) is a highly aggressive tumor subtype associated with a poor prognosis. The mechanism involved in TNBC progression remains largely unknown. To date, there are no effective therapeutic targets for this tumor subtype. In this study, by performing quantitative proteo...

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Veröffentlicht in:	Oncotarget 2015-06, Vol.6 (18), p.16352-16365
Hauptverfasser:	Jiang, Hong-Lin, Sun, He-Fen, Gao, Shui-Ping, Li, Liang-Dong, Hu, Xin, Wu, Jiong, Jin, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers, Tumor - genetics Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - mortality Carcinoma, Ductal, Breast - pathology Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Down-Regulation Enzyme Activation - genetics Epithelial-Mesenchymal Transition - genetics Female Gene Expression Regulation, Neoplastic HEK293 Cells Heterografts Humans Lung Neoplasms - secondary Mice Mice, Inbred BALB C Mice, Nude Middle Aged Neoplasm Transplantation Prognosis rab1 GTP-Binding Proteins - genetics Receptors, Transforming Growth Factor beta - metabolism Research Paper RNA Interference RNA, Small Interfering Signal Transduction - genetics Smad3 Protein - metabolism Tissue Array Analysis Transforming Growth Factor beta - metabolism Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - mortality Triple Negative Breast Neoplasms - pathology Ubiquitin - metabolism
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