Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function

Aging is driven by changes of the epigenetic state that are only partially understood. We performed a comprehensive epigenomic analysis of the pancreatic β cell, key player in glucose homeostasis, in adolescent and very old mice. We observe a global methylation drift resulting in an overall more lev...

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Veröffentlicht in:	Cell metabolism 2015-10, Vol.22 (4), p.619-632
Hauptverfasser:	Avrahami, Dana, Li, Changhong, Zhang, Jia, Schug, Jonathan, Avrahami, Ran, Rao, Shilpa, Stadler, Michael B., Burger, Lukas, Schübeler, Dirk, Glaser, Benjamin, Kaestner, Klaus H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Cell Proliferation Cells, Cultured Chromatin - metabolism CpG Islands DNA Methylation Enhancer Elements, Genetic - genetics Histones - genetics Histones - metabolism Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - cytology Insulin-Secreting Cells - metabolism Male Mice Mice, Inbred C57BL Promoter Regions, Genetic Protein Binding Transcription Factors - chemistry Transcription Factors - metabolism
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