Photoactivatable genetically encoded calcium indicators for targeted neuronal imaging

The photoactivatable calcium sensors reported in this paper allow simultaneous highlighting of cellular morphology and recording of calcium activity, which is demonstrated in neuronal cultures, in Drosophila and in zebrafish. Circuit mapping requires knowledge of both structural and functional conne...

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Veröffentlicht in:	Nature methods 2015-09, Vol.12 (9), p.852-858
Hauptverfasser:	Berlin, Shai, Carroll, Elizabeth C, Newman, Zachary L, Okada, Hitomi O, Quinn, Carson M, Kallman, Benjamin, Rockwell, Nathan C, Martin, Shelley S, Lagarias, J Clark, Isacoff, Ehud Y
Format:	Artikel
Sprache:	eng
Schlagworte:	14 14/19 14/35 631/378/87 Animals Bioinformatics Biological Microscopy Biological Techniques Biomedical and Life Sciences Biomedical Engineering/Biotechnology Calcium - metabolism Calcium Signaling - physiology Cell Tracking - methods Cells, Cultured Cellular biology Danio rerio Drosophila Fluorescent proteins Fruits Larvae Life Sciences Light Luminescent Proteins - genetics Luminescent Proteins - metabolism Medical research Medicine, Experimental Methods Microscopy, Fluorescence - methods Morphology Neuroimaging Neurons Neurons - cytology Neurons - physiology Optogenetics - methods Population density Probes Protein Engineering - methods Proteins Proteomics Rats Sensors Zebrafish
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