Conformational dynamics of a class C G-protein-coupled receptor

smFRET is used to probe the activation mechanism of two full-length mammalian glutamate receptors, revealing that the extracellular ligand-binding domains of these G-protein-coupled receptors interconvert between three confirmations (resting, activated and a short-lived intermediate state), and that...

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Veröffentlicht in:	Nature (London) 2015-08, Vol.524 (7566), p.497-501
Hauptverfasser:	Vafabakhsh, Reza, Levitz, Joshua, Isacoff, Ehud Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	14 14/33 631/57/2265 631/92/612/194 9/74 Animals Binding Sites Correlation analysis Drug Partial Agonism Energy transfer Fluorescence Resonance Energy Transfer G proteins Histograms Humanities and Social Sciences Humans letter Ligands Membrane proteins Models, Biological Models, Molecular multidisciplinary Protein Binding Protein Conformation Protein research Proteins Rats Receptors, Metabotropic Glutamate - chemistry Receptors, Metabotropic Glutamate - classification Receptors, Metabotropic Glutamate - genetics Receptors, Metabotropic Glutamate - metabolism Science Studies
Online-Zugang:	Volltext
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