Successful recanalization post endovascular therapy is associated with a decreased risk of intracranial haemorrhage: a retrospective study
The risks of intracranial haemorrhage (ICH) post intra-arterial therapy (IAT) for stroke are not well understood. We aimed to study the influence of recanalization status post IAT for anterior circulation stroke and posterior circulation stroke on ICH development. Retrospective analysis of 193 patie...
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| Veröffentlicht in: | BMC neurology 2015-10, Vol.15 (1), p.185-185, Article 185 |
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| creator | Wang, David T Churilov, Leonid Dowling, Richard Mitchell, Peter Yan, Bernard |
| description | The risks of intracranial haemorrhage (ICH) post intra-arterial therapy (IAT) for stroke are not well understood. We aimed to study the influence of recanalization status post IAT for anterior circulation stroke and posterior circulation stroke on ICH development.
Retrospective analysis of 193 patients in a prospectively collected database of IAT stroke patients was performed. Successful recanalization was defined as a Thrombolysis in Cerebral Infarction Score of 2b or 3 and symptomatic ICH (SICH) as parenchymal hematoma type 2 (PH2) with neurological deterioration. The association between the recanalization status and ICH/SICH was investigated using logistic regression models adjusted for baseline characteristics selected by univariate analyses.
One hundred and thirty-six patients had successful recanalization post procedure, 41 patients developed ICH and 10 patients SICH. There was a statistically significant baseline imbalance between the groups with and without successful recanalization on gender, baseline National Institute of Health Stroke Scale (NIHSS) score, the use of intravenous tPA and intra-arterial urokinase (p < 0.05). Logistic regression analysis adjusted for the above variables and the time to digital subtraction angiography demonstrated a statistically significant association between successful recanalization and ICH (odds ratio 0.42; 95% CI 0.19, 0.95; p = 0.04).
Successful recanalization post endovascular therapy is statistically significantly and negatively associated with ICH. |
| doi_str_mv | 10.1186/s12883-015-0442-x |
| format | Article |
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Retrospective analysis of 193 patients in a prospectively collected database of IAT stroke patients was performed. Successful recanalization was defined as a Thrombolysis in Cerebral Infarction Score of 2b or 3 and symptomatic ICH (SICH) as parenchymal hematoma type 2 (PH2) with neurological deterioration. The association between the recanalization status and ICH/SICH was investigated using logistic regression models adjusted for baseline characteristics selected by univariate analyses.
One hundred and thirty-six patients had successful recanalization post procedure, 41 patients developed ICH and 10 patients SICH. There was a statistically significant baseline imbalance between the groups with and without successful recanalization on gender, baseline National Institute of Health Stroke Scale (NIHSS) score, the use of intravenous tPA and intra-arterial urokinase (p < 0.05). Logistic regression analysis adjusted for the above variables and the time to digital subtraction angiography demonstrated a statistically significant association between successful recanalization and ICH (odds ratio 0.42; 95% CI 0.19, 0.95; p = 0.04).
Successful recanalization post endovascular therapy is statistically significantly and negatively associated with ICH.</description><identifier>ISSN: 1471-2377</identifier><identifier>EISSN: 1471-2377</identifier><identifier>DOI: 10.1186/s12883-015-0442-x</identifier><identifier>PMID: 26445968</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Aged ; Australia - epidemiology ; Female ; Humans ; Intracranial Hemorrhages - epidemiology ; Logistic Models ; Male ; Middle Aged ; Retrospective Studies ; Stroke - therapy ; Thrombolytic Therapy</subject><ispartof>BMC neurology, 2015-10, Vol.15 (1), p.185-185, Article 185</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2015</rights><rights>Wang et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-41c7ef1a6456725ca13a799ad3faaa8703a6fcb227054d502d22075ac6c4b93a3</citedby><cites>FETCH-LOGICAL-c494t-41c7ef1a6456725ca13a799ad3faaa8703a6fcb227054d502d22075ac6c4b93a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597389/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597389/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26445968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, David T</creatorcontrib><creatorcontrib>Churilov, Leonid</creatorcontrib><creatorcontrib>Dowling, Richard</creatorcontrib><creatorcontrib>Mitchell, Peter</creatorcontrib><creatorcontrib>Yan, Bernard</creatorcontrib><title>Successful recanalization post endovascular therapy is associated with a decreased risk of intracranial haemorrhage: a retrospective study</title><title>BMC neurology</title><addtitle>BMC Neurol</addtitle><description>The risks of intracranial haemorrhage (ICH) post intra-arterial therapy (IAT) for stroke are not well understood. We aimed to study the influence of recanalization status post IAT for anterior circulation stroke and posterior circulation stroke on ICH development.
Retrospective analysis of 193 patients in a prospectively collected database of IAT stroke patients was performed. Successful recanalization was defined as a Thrombolysis in Cerebral Infarction Score of 2b or 3 and symptomatic ICH (SICH) as parenchymal hematoma type 2 (PH2) with neurological deterioration. The association between the recanalization status and ICH/SICH was investigated using logistic regression models adjusted for baseline characteristics selected by univariate analyses.
One hundred and thirty-six patients had successful recanalization post procedure, 41 patients developed ICH and 10 patients SICH. There was a statistically significant baseline imbalance between the groups with and without successful recanalization on gender, baseline National Institute of Health Stroke Scale (NIHSS) score, the use of intravenous tPA and intra-arterial urokinase (p < 0.05). Logistic regression analysis adjusted for the above variables and the time to digital subtraction angiography demonstrated a statistically significant association between successful recanalization and ICH (odds ratio 0.42; 95% CI 0.19, 0.95; p = 0.04).
Successful recanalization post endovascular therapy is statistically significantly and negatively associated with ICH.</description><subject>Aged</subject><subject>Australia - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Intracranial Hemorrhages - epidemiology</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Stroke - therapy</subject><subject>Thrombolytic Therapy</subject><issn>1471-2377</issn><issn>1471-2377</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptks1u1DAUhSMEoqXwAGyQJTZsUvwbJyyQqoo_qRILYG3dcW4mLkkcbGfa4RF4ahxNKS1CXti6_s6RfXSK4jmjp4zV1evIeF2LkjJVUil5ef2gOGZSs5ILrR_eOR8VT2K8pJTpWrLHxRGvpFRNVR8Xv74s1mKM3TKQgBYmGNxPSM5PZPYxEZxav4NolwECST0GmPfERQIxeusgYUuuXOoJkBZtQIh5EFz8TnxH3JQC2ACTg4H0gKMPoYctvsl0wBR8nNEmt0MS09LunxaPOhgiPrvZT4pv7999Pf9YXnz-8On87KK0spGplMxq7BhUUlWaKwtMgG4aaEUHALWmAqrObjjXVMlWUd5yTrUCW1m5aQSIk-LtwXdeNiO2FtdnDmYOboSwNx6cuX8zud5s_c7kyLSom2zw6sYg-B8LxmRGFy0OA0zol2iY5kzIhlU0oy__QS_9EnLIK6Ubzaiq6r_UFgY0bur8Gtxqas6UZKJRvOKZOv0PlVeLo7N-ws7l-T0BOwhsjjoG7G7_yKhZC2QOBTK5QGYtkLnOmhd3w7lV_GmM-A0u3sQv</recordid><startdate>20151007</startdate><enddate>20151007</enddate><creator>Wang, David T</creator><creator>Churilov, Leonid</creator><creator>Dowling, Richard</creator><creator>Mitchell, Peter</creator><creator>Yan, Bernard</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151007</creationdate><title>Successful recanalization post endovascular therapy is associated with a decreased risk of intracranial haemorrhage: a retrospective study</title><author>Wang, David T ; Churilov, Leonid ; Dowling, Richard ; Mitchell, Peter ; Yan, Bernard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-41c7ef1a6456725ca13a799ad3faaa8703a6fcb227054d502d22075ac6c4b93a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Australia - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Intracranial Hemorrhages - epidemiology</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Stroke - therapy</topic><topic>Thrombolytic Therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, David T</creatorcontrib><creatorcontrib>Churilov, Leonid</creatorcontrib><creatorcontrib>Dowling, Richard</creatorcontrib><creatorcontrib>Mitchell, Peter</creatorcontrib><creatorcontrib>Yan, Bernard</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, David T</au><au>Churilov, Leonid</au><au>Dowling, Richard</au><au>Mitchell, Peter</au><au>Yan, Bernard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful recanalization post endovascular therapy is associated with a decreased risk of intracranial haemorrhage: a retrospective study</atitle><jtitle>BMC neurology</jtitle><addtitle>BMC Neurol</addtitle><date>2015-10-07</date><risdate>2015</risdate><volume>15</volume><issue>1</issue><spage>185</spage><epage>185</epage><pages>185-185</pages><artnum>185</artnum><issn>1471-2377</issn><eissn>1471-2377</eissn><abstract>The risks of intracranial haemorrhage (ICH) post intra-arterial therapy (IAT) for stroke are not well understood. We aimed to study the influence of recanalization status post IAT for anterior circulation stroke and posterior circulation stroke on ICH development.
Retrospective analysis of 193 patients in a prospectively collected database of IAT stroke patients was performed. Successful recanalization was defined as a Thrombolysis in Cerebral Infarction Score of 2b or 3 and symptomatic ICH (SICH) as parenchymal hematoma type 2 (PH2) with neurological deterioration. The association between the recanalization status and ICH/SICH was investigated using logistic regression models adjusted for baseline characteristics selected by univariate analyses.
One hundred and thirty-six patients had successful recanalization post procedure, 41 patients developed ICH and 10 patients SICH. There was a statistically significant baseline imbalance between the groups with and without successful recanalization on gender, baseline National Institute of Health Stroke Scale (NIHSS) score, the use of intravenous tPA and intra-arterial urokinase (p < 0.05). Logistic regression analysis adjusted for the above variables and the time to digital subtraction angiography demonstrated a statistically significant association between successful recanalization and ICH (odds ratio 0.42; 95% CI 0.19, 0.95; p = 0.04).
Successful recanalization post endovascular therapy is statistically significantly and negatively associated with ICH.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26445968</pmid><doi>10.1186/s12883-015-0442-x</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | BMC neurology, 2015-10, Vol.15 (1), p.185-185, Article 185 |
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| source | Directory of Open Access Journals (DOAJ); SpringerOpen; MEDLINE; SpringerLINK Journals; PubMed Central; EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | Aged Australia - epidemiology Female Humans Intracranial Hemorrhages - epidemiology Logistic Models Male Middle Aged Retrospective Studies Stroke - therapy Thrombolytic Therapy |
| title | Successful recanalization post endovascular therapy is associated with a decreased risk of intracranial haemorrhage: a retrospective study |
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