Epithelial PD-L2 Expression Marks Barrett's Esophagus and Esophageal Adenocarcinoma

Esophageal adenocarcinoma is an increasingly common disease with a dismal 5-year survival rate of 10% to 15%. In the first systematic evaluation of the PD-1 pathway in esophageal adenocarcinoma, we identify expression of PD-L2 in cancer cells in 51.7% of esophageal adenocarcinomas. Epithelial PD-L1...

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Veröffentlicht in:	Cancer immunology research 2015-10, Vol.3 (10), p.1123-1129
Hauptverfasser:	Derks, Sarah, Nason, Katie S, Liao, Xiaoyun, Stachler, Matthew D, Liu, Kevin X, Liu, Jie Bin, Sicinska, Ewa, Goldberg, Michael S, Freeman, Gordon J, Rodig, Scott J, Davison, Jon M, Bass, Adam J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Aged Animals B7-H1 Antigen - genetics B7-H1 Antigen - metabolism Barrett Esophagus - genetics Barrett Esophagus - metabolism Barrett Esophagus - pathology Biomarkers Cell Line, Tumor Disease Models, Animal Disease Progression Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Female Gene Expression Heterografts Humans Immunohistochemistry Interleukin-13 - metabolism Interleukin-4 - metabolism Male Mice Middle Aged Mucous Membrane - metabolism Mucous Membrane - pathology Neoplasm Grading Neoplasm Metastasis Neoplasm Staging Programmed Cell Death 1 Ligand 2 Protein - genetics Programmed Cell Death 1 Ligand 2 Protein - metabolism Programmed Cell Death 1 Receptor - genetics Programmed Cell Death 1 Receptor - metabolism Reproducibility of Results Signal Transduction Tumor Burden
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