Effects of p67phox on the mitochondrial oxidative state in the kidney of Dahl salt-sensitive rats: optical fluorescence 3-D cryoimaging

The goal of the present study was to quantify and correlate the contribution of the cytosolic p67(phox) subunit of NADPH oxidase 2 to mitochondrial oxidative stress in the kidneys of the Dahl salt-sensitive (SS) hypertensive rat. Whole kidney redox states were uniquely assessed using a custom-design...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2015-08, Vol.309 (4), p.F377-F382
Hauptverfasser:	Salehpour, F, Ghanian, Z, Yang, C, Zheleznova, N N, Kurth, T, Dash, R K, Cowley, Jr, A W, Ranji, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Flavin-Adenine Dinucleotide - metabolism Frozen Sections Genotype Hypertension - chemically induced Hypertension - enzymology Hypertension - genetics Hypertension - pathology Image Processing, Computer-Assisted Imaging, Three-Dimensional - instrumentation Imaging, Three-Dimensional - methods Kidney - enzymology Kidney - pathology Male Microscopy, Fluorescence - instrumentation Microscopy, Fluorescence - methods Mitochondria - enzymology Mitochondria - pathology NAD - metabolism Oxidation-Reduction Oxidative Stress Phenotype Phosphoproteins - deficiency Phosphoproteins - genetics Phosphoproteins - metabolism Rats, Inbred Dahl Rats, Transgenic Sodium Chloride, Dietary Time Factors
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