Pulmonary vascular lesions in the toxic oil syndrome in Spain
A histological study was made of pulmonary arteries at the necropsies of nine patients who died after the ingestion of denatured rapeseed oil during the epidemic which occurred in Spain in May 1981. Lesions found in the elastic pulmonary arteries were characterised by pronounced intimal proliferatio...
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| Veröffentlicht in: | Thorax 1983-10, Vol.38 (10), p.724-729 |
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| creator | Fernández-Segoviano, P Esteban, A Martínez-Cabruja, R |
| description | A histological study was made of pulmonary arteries at the necropsies of nine patients who died after the ingestion of denatured rapeseed oil during the epidemic which occurred in Spain in May 1981. Lesions found in the elastic pulmonary arteries were characterised by pronounced intimal proliferation of an oedematous nature, accumulation of large vacuolated cells within the media, and loss of vascular smooth muscle. In muscular pulmonary arteries there was pronounced medial hypertrophy and intimal proliferation, which was so severe in one case that it completely occluded the arterial lumen. Foamy cells were found in the intima. Muscularisation was seen in the walls of pulmonary arterioles. |
| doi_str_mv | 10.1136/thx.38.10.724 |
| format | Article |
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Lesions found in the elastic pulmonary arteries were characterised by pronounced intimal proliferation of an oedematous nature, accumulation of large vacuolated cells within the media, and loss of vascular smooth muscle. In muscular pulmonary arteries there was pronounced medial hypertrophy and intimal proliferation, which was so severe in one case that it completely occluded the arterial lumen. Foamy cells were found in the intima. 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Lesions found in the elastic pulmonary arteries were characterised by pronounced intimal proliferation of an oedematous nature, accumulation of large vacuolated cells within the media, and loss of vascular smooth muscle. In muscular pulmonary arteries there was pronounced medial hypertrophy and intimal proliferation, which was so severe in one case that it completely occluded the arterial lumen. Foamy cells were found in the intima. Muscularisation was seen in the walls of pulmonary arterioles.</description><subject>Adult</subject><subject>Aged</subject><subject>Arteries - pathology</subject><subject>Arterioles - pathology</subject><subject>Biological and medical sciences</subject><subject>Brassica</subject><subject>Brassica campestris</subject><subject>Elastic Tissue - pathology</subject><subject>Female</subject><subject>Food toxicology</subject><subject>Humans</subject><subject>Hypertension, Pulmonary - chemically induced</subject><subject>Hypertension, Pulmonary - pathology</subject><subject>Lung - blood supply</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Muscle, Smooth, Vascular - pathology</subject><subject>Myocardium - pathology</subject><subject>Oils - poisoning</subject><subject>Toxicology</subject><issn>0040-6376</issn><issn>1468-3296</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkc1LHDEYh4NY7Go9ehQGLOJltvmafBw8FFFbEBRazyGTTbpZMsk2mRH975tll6X20lN4-T1v8gsPAGcIzhEi7Mu4fJ0TMa8jx_QAzBBloiVYskMwg5DClhHOPoLjUlYQQoEQPwJHjFEhOjgD109TGFLU-a150cVMQecm2OJTLI2Pzbi0zZhevWmSD015i4ucBrtJfqy1j5_AB6dDsae78wQ8393-vPnWPjzef7_5-tD2HcRjqx3vqaRC95hRyJizHdPSOWmxpsRJyomBbtEjaSW0UHcO95Wj0jjmmFmQE3C9vXc99YNdGBvHrINaZz_U5ippr94n0S_Vr_SiaCcZZXX_cref0-_JllENvhgbgo42TUUhShgWnFfw4h9wlaYc698U4hxhKYXsKtVuKZNTKdm6fRME1UaKqlIUEZuxSqn8-d_19_TOQs0_7_KqQAeXdTS-7DFJBO4kqdjVFuuH1X9e_AOca6KV</recordid><startdate>19831001</startdate><enddate>19831001</enddate><creator>Fernández-Segoviano, P</creator><creator>Esteban, A</creator><creator>Martínez-Cabruja, R</creator><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7U7</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>19831001</creationdate><title>Pulmonary vascular lesions in the toxic oil syndrome in Spain</title><author>Fernández-Segoviano, P ; Esteban, A ; Martínez-Cabruja, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b502t-af7b4948ab264066fe56a9ff9e2a43f9473c0fdb19e90e0a5f2b40649cf6f6cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Arteries - pathology</topic><topic>Arterioles - pathology</topic><topic>Biological and medical sciences</topic><topic>Brassica</topic><topic>Brassica campestris</topic><topic>Elastic Tissue - pathology</topic><topic>Female</topic><topic>Food toxicology</topic><topic>Humans</topic><topic>Hypertension, Pulmonary - chemically induced</topic><topic>Hypertension, Pulmonary - pathology</topic><topic>Lung - blood supply</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Muscle, Smooth, Vascular - pathology</topic><topic>Myocardium - pathology</topic><topic>Oils - poisoning</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernández-Segoviano, P</creatorcontrib><creatorcontrib>Esteban, A</creatorcontrib><creatorcontrib>Martínez-Cabruja, R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Thorax</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernández-Segoviano, P</au><au>Esteban, A</au><au>Martínez-Cabruja, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary vascular lesions in the toxic oil syndrome in Spain</atitle><jtitle>Thorax</jtitle><addtitle>Thorax</addtitle><date>1983-10-01</date><risdate>1983</risdate><volume>38</volume><issue>10</issue><spage>724</spage><epage>729</epage><pages>724-729</pages><issn>0040-6376</issn><eissn>1468-3296</eissn><coden>THORA7</coden><abstract>A histological study was made of pulmonary arteries at the necropsies of nine patients who died after the ingestion of denatured rapeseed oil during the epidemic which occurred in Spain in May 1981. Lesions found in the elastic pulmonary arteries were characterised by pronounced intimal proliferation of an oedematous nature, accumulation of large vacuolated cells within the media, and loss of vascular smooth muscle. In muscular pulmonary arteries there was pronounced medial hypertrophy and intimal proliferation, which was so severe in one case that it completely occluded the arterial lumen. Foamy cells were found in the intima. Muscularisation was seen in the walls of pulmonary arterioles.</abstract><cop>London</cop><pub>BMJ</pub><pmid>6648850</pmid><doi>10.1136/thx.38.10.724</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Arteries - pathology Arterioles - pathology Biological and medical sciences Brassica Brassica campestris Elastic Tissue - pathology Female Food toxicology Humans Hypertension, Pulmonary - chemically induced Hypertension, Pulmonary - pathology Lung - blood supply Male Medical sciences Middle Aged Muscle, Smooth, Vascular - pathology Myocardium - pathology Oils - poisoning Toxicology |
| title | Pulmonary vascular lesions in the toxic oil syndrome in Spain |
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