Pharmacological Modulation of the Mitochondrial Electron Transport Chain in Paclitaxel-Induced Painful Peripheral Neuropathy

Abstract Paclitaxel is an effective first-line chemotherapeutic with the major dose-limiting side effect of painful neuropathy. Mitochondrial dysfunction and oxidative stress have been implicated in paclitaxel-induced painful neuropathy. Here we show the effects of pharmacological modulation of mito...

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Veröffentlicht in:	The journal of pain 2015-10, Vol.16 (10), p.981-994
Hauptverfasser:	Griffiths, Lisa A, Flatters, Sarah J.L
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia & Perioperative Care Animals Antimycin A - analogs & derivatives Antimycin A - pharmacology Antineoplastic Agents, Phytogenic - toxicity chemotherapy-induced neuropathy Disease Models, Animal Electron Transport Electron Transport Chain Complex Proteins - metabolism Enzyme Inhibitors - pharmacology Hyperalgesia - physiopathology Male Mitochondria Motor Activity - drug effects Original Report paclitaxel Paclitaxel - toxicity pain Pain - chemically induced Pain Measurement Pain Medicine Peripheral Nervous System Diseases - chemically induced Psychomotor Disorders - etiology Rats Rats, Sprague-Dawley Rotenone - pharmacology Single-Blind Method Taxol Time Factors
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