Epigenetic silencing of the XAF1 gene is mediated by the loss of CTCF binding

XAF1 is a tumour suppressor gene that compromises cell viability by modulating different cellular events such as mitosis, cell cycle progression and apoptosis. In cancer, the XAF1 gene is commonly silenced by CpG-dinucleotide hypermethylation of its promoter. DNA demethylating agents induce transcri...

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Veröffentlicht in:	Scientific reports 2015-10, Vol.5 (1), p.14838-14838, Article 14838
Hauptverfasser:	Victoria-Acosta, Georgina, Vazquez-Santillan, Karla, Jimenez-Hernandez, Luis, Muñoz-Galindo, Laura, Maldonado, Vilma, Martinez-Ruiz, Gustavo Ulises, Melendez-Zajgla, Jorge
Format:	Artikel
Sprache:	eng
Schlagworte:	45/15 45/22 631/337/176/2016 631/67/69 Apoptosis Blotting, Western Cancer CCCTC-Binding Factor Cell cycle Cell Survival Chromatin Chromatin Immunoprecipitation CpG islands DNA Methylation Epigenesis, Genetic - genetics Epigenetics Gene Expression Regulation, Neoplastic Gene Silencing Humanities and Social Sciences Humans Immunoprecipitation Intracellular Signaling Peptides and Proteins - genetics Methylation Mitosis Molecular modelling multidisciplinary Neoplasm Proteins - genetics Promoter Regions, Genetic - genetics Real-Time Polymerase Chain Reaction Repressor Proteins - genetics Repressor Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Science Transcription activation Tumor Cells, Cultured Tumors
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