Combinatorial Immunoprofiling in Latent Tuberculosis Infection. Toward Better Risk Stratification

Most immunocompetent patients diagnosed with latent tuberculosis infection (LTBI) will not progress to tuberculosis (TB) reactivation. However, current diagnostic tools cannot reliably distinguish nonprogressing from progressing patients a priori, and thus LTBI therapy must be prescribed with subopt...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2015-09, Vol.192 (5), p.605-617
Hauptverfasser:	Escalante, Patricio, Peikert, Tobias, Van Keulen, Virginia P, Erskine, Courtney L, Bornhorst, Cathy L, Andrist, Boleyn R, McCoy, Kevin, Pease, Larry R, Abraham, Roshini S, Knutson, Keith L, Kita, Hirohito, Schrum, Adam G, Limper, Andrew H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers CD4-Positive T-Lymphocytes - immunology Cohort Studies Female Flow Cytometry Humans Immunoassay Immunocompetence - immunology Interferon-gamma Release Tests Interleukin-2 Receptor alpha Subunit - immunology Latent Tuberculosis - immunology Male Middle Aged Original Receptors, OX40 - immunology Risk Assessment ROC Curve T-Lymphocytes - immunology Young Adult
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