Endothelin-1 induces LIMK2-mediated programmed necrotic neuronal death independent of NOS activity

Recently, we have reported that LIM kinase 2 (LIMK2) involves programmed necrotic neuronal deaths induced by aberrant cyclin D1 expression following status epilepticus (SE). Up-regulation of LIMK2 expression induces neuronal necrosis by impairment of dynamin-related protein 1 (DRP1)-mediated mitocho...

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Veröffentlicht in:	Molecular brain 2015-10, Vol.8 (1), p.58-58, Article 58
Hauptverfasser:	Ko, Ah-Reum, Hyun, Hye-Won, Min, Su-Ji, Kim, Ji-Eun, Kang, Tae-Cheon
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - pharmacology Animals Apoptosis - drug effects Blood-Brain Barrier - drug effects Blood-Brain Barrier - pathology Care and treatment Caveolin 1 - pharmacology Complications and side effects Endothelin Endothelin-1 - genetics Endothelin-1 - metabolism Epilepsy Hippocampus - pathology Investigations Lim Kinases - metabolism Male Mitochondrial Dynamics - drug effects Models, Biological Necrosis Neurons Neurons - metabolism Neurons - pathology Nitric Oxide Synthase Type I - metabolism Oligopeptides - pharmacology Peptides - pharmacology Piperidines - pharmacology Pyridines - pharmacology Rats, Sprague-Dawley Receptors, Endothelin - metabolism rho-Associated Kinases - metabolism RNA RNA, Messenger - genetics RNA, Messenger - metabolism Status Epilepticus - genetics Status Epilepticus - pathology Utrophin
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