Carboxyhaemoglobin and pulmonary epithelial permeability in man

The effect of cigarette smoke exposure on pulmonary epithelial permeability was studied in 45 smokers and 22 non-smokers. An index of cigarette smoke exposure was obtained from the carboxyhaemoglobin concentration (HbCO%). Pulmonary epithelial permeability was proportional to the half-time clearance...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Thorax 1983-02, Vol.38 (2), p.129-133
Hauptverfasser: Jones, J G, Minty, B D, Royston, D, Royston, J P
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 133
container_issue 2
container_start_page 129
container_title Thorax
container_volume 38
creator Jones, J G
Minty, B D
Royston, D
Royston, J P
description The effect of cigarette smoke exposure on pulmonary epithelial permeability was studied in 45 smokers and 22 non-smokers. An index of cigarette smoke exposure was obtained from the carboxyhaemoglobin concentration (HbCO%). Pulmonary epithelial permeability was proportional to the half-time clearance rate of technetium-99m-labelled diethylene triamine pentacetate (99mTc DTPA) from lung to blood (T1/2LB). The relationship between T1/2LB and HbCO% was hyperbolic in form and the data could be fitted to the quadratic formula (formula; see text) where the parameters a0, a1, and a2 represent respectively the asymptotic T1/2LB value at large carboxyhaemoglobin values and the slope and shape of the curve. The values of these parameters were a0 4.4 (2.6), a1 = 77.8 (15.5), and a2 -25.5 (9.7) (SE). This is the first demonstration of a dose-response relationship between carboxyhaemoglobin and an increased permeability of the lungs in man and provides a technique for identifying the roles of carbon monoxide and other cigarette smoke constituents in causing increased pulmonary epithelial permeability.
doi_str_mv 10.1136/thx.38.2.129
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_459501</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>80510893</sourcerecordid><originalsourceid>FETCH-LOGICAL-b3919-eba85e4bf435c3b859b46dfca39086ff3e7c05982af013cf9fa2e9854ddfae7a3</originalsourceid><addsrcrecordid>eNp9kcuP0zAQxi0EWrqFG1ekSEhwIcWOH7EPCKFoX6KCAw8hLpad2FsXJw52gtr_Hq9aVSwHTnP4fjPzzXwAPENwhRBmb6bNboX5qlqhSjwAC0QYL3El2EOwgJDAkuGaPQbnKW0hhByh-gycMUwIRnAB3jUq6rDbb5Tpw60P2g2FGrpinH0fBhX3hRndtDHeKV-MJvZGaefdtC8y2KvhCXhklU_m6bEuwdfLiy_Ndbn-dHXTvF-XGgskSqMVp4ZoSzBtseZUaMI62yosIGfWYlO3kApeKQsRbq2wqjKCU9J1Vpla4SV4e5g7zro3XWuGKSovx-j6bFIG5eR9ZXAbeRt-S0IFzSOX4OWxP4Zfs0mT7F1qjfdqMGFOkkOKIBc4gy_-AbdhjkO-TaK6zi8Wgt5Rrw9UG0NK0diTEwTlXSoypyIxl5XMLRl__rf7E3yMIevlQXdpMruTrOJPyWpcU_nxWyObz9X68gP-Ln9k_tWB1_32_5v_AJ7OpjA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1771299953</pqid></control><display><type>article</type><title>Carboxyhaemoglobin and pulmonary epithelial permeability in man</title><source>PubMed (Medline)</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Jones, J G ; Minty, B D ; Royston, D ; Royston, J P</creator><creatorcontrib>Jones, J G ; Minty, B D ; Royston, D ; Royston, J P</creatorcontrib><description>The effect of cigarette smoke exposure on pulmonary epithelial permeability was studied in 45 smokers and 22 non-smokers. An index of cigarette smoke exposure was obtained from the carboxyhaemoglobin concentration (HbCO%). Pulmonary epithelial permeability was proportional to the half-time clearance rate of technetium-99m-labelled diethylene triamine pentacetate (99mTc DTPA) from lung to blood (T1/2LB). The relationship between T1/2LB and HbCO% was hyperbolic in form and the data could be fitted to the quadratic formula (formula; see text) where the parameters a0, a1, and a2 represent respectively the asymptotic T1/2LB value at large carboxyhaemoglobin values and the slope and shape of the curve. The values of these parameters were a0 4.4 (2.6), a1 = 77.8 (15.5), and a2 -25.5 (9.7) (SE). This is the first demonstration of a dose-response relationship between carboxyhaemoglobin and an increased permeability of the lungs in man and provides a technique for identifying the roles of carbon monoxide and other cigarette smoke constituents in causing increased pulmonary epithelial permeability.</description><identifier>ISSN: 0040-6376</identifier><identifier>EISSN: 1468-3296</identifier><identifier>DOI: 10.1136/thx.38.2.129</identifier><identifier>PMID: 6344310</identifier><identifier>CODEN: THORA7</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and British Thoracic Society</publisher><subject>Adult ; Aged ; Carboxyhemoglobin - analysis ; Cell Membrane Permeability ; Hemoglobins - analysis ; Humans ; Middle Aged ; Pentetic Acid ; Pulmonary Alveoli - metabolism ; Smoking ; Technetium ; Technetium Tc 99m Pentetate ; Time Factors</subject><ispartof>Thorax, 1983-02, Vol.38 (2), p.129-133</ispartof><rights>Copyright BMJ Publishing Group LTD Feb 1983</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b3919-eba85e4bf435c3b859b46dfca39086ff3e7c05982af013cf9fa2e9854ddfae7a3</citedby><cites>FETCH-LOGICAL-b3919-eba85e4bf435c3b859b46dfca39086ff3e7c05982af013cf9fa2e9854ddfae7a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC459501/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC459501/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6344310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jones, J G</creatorcontrib><creatorcontrib>Minty, B D</creatorcontrib><creatorcontrib>Royston, D</creatorcontrib><creatorcontrib>Royston, J P</creatorcontrib><title>Carboxyhaemoglobin and pulmonary epithelial permeability in man</title><title>Thorax</title><addtitle>Thorax</addtitle><description>The effect of cigarette smoke exposure on pulmonary epithelial permeability was studied in 45 smokers and 22 non-smokers. An index of cigarette smoke exposure was obtained from the carboxyhaemoglobin concentration (HbCO%). Pulmonary epithelial permeability was proportional to the half-time clearance rate of technetium-99m-labelled diethylene triamine pentacetate (99mTc DTPA) from lung to blood (T1/2LB). The relationship between T1/2LB and HbCO% was hyperbolic in form and the data could be fitted to the quadratic formula (formula; see text) where the parameters a0, a1, and a2 represent respectively the asymptotic T1/2LB value at large carboxyhaemoglobin values and the slope and shape of the curve. The values of these parameters were a0 4.4 (2.6), a1 = 77.8 (15.5), and a2 -25.5 (9.7) (SE). This is the first demonstration of a dose-response relationship between carboxyhaemoglobin and an increased permeability of the lungs in man and provides a technique for identifying the roles of carbon monoxide and other cigarette smoke constituents in causing increased pulmonary epithelial permeability.</description><subject>Adult</subject><subject>Aged</subject><subject>Carboxyhemoglobin - analysis</subject><subject>Cell Membrane Permeability</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Pentetic Acid</subject><subject>Pulmonary Alveoli - metabolism</subject><subject>Smoking</subject><subject>Technetium</subject><subject>Technetium Tc 99m Pentetate</subject><subject>Time Factors</subject><issn>0040-6376</issn><issn>1468-3296</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kcuP0zAQxi0EWrqFG1ekSEhwIcWOH7EPCKFoX6KCAw8hLpad2FsXJw52gtr_Hq9aVSwHTnP4fjPzzXwAPENwhRBmb6bNboX5qlqhSjwAC0QYL3El2EOwgJDAkuGaPQbnKW0hhByh-gycMUwIRnAB3jUq6rDbb5Tpw60P2g2FGrpinH0fBhX3hRndtDHeKV-MJvZGaefdtC8y2KvhCXhklU_m6bEuwdfLiy_Ndbn-dHXTvF-XGgskSqMVp4ZoSzBtseZUaMI62yosIGfWYlO3kApeKQsRbq2wqjKCU9J1Vpla4SV4e5g7zro3XWuGKSovx-j6bFIG5eR9ZXAbeRt-S0IFzSOX4OWxP4Zfs0mT7F1qjfdqMGFOkkOKIBc4gy_-AbdhjkO-TaK6zi8Wgt5Rrw9UG0NK0diTEwTlXSoypyIxl5XMLRl__rf7E3yMIevlQXdpMruTrOJPyWpcU_nxWyObz9X68gP-Ln9k_tWB1_32_5v_AJ7OpjA</recordid><startdate>19830201</startdate><enddate>19830201</enddate><creator>Jones, J G</creator><creator>Minty, B D</creator><creator>Royston, D</creator><creator>Royston, J P</creator><general>BMJ Publishing Group Ltd and British Thoracic Society</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19830201</creationdate><title>Carboxyhaemoglobin and pulmonary epithelial permeability in man</title><author>Jones, J G ; Minty, B D ; Royston, D ; Royston, J P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b3919-eba85e4bf435c3b859b46dfca39086ff3e7c05982af013cf9fa2e9854ddfae7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Carboxyhemoglobin - analysis</topic><topic>Cell Membrane Permeability</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Pentetic Acid</topic><topic>Pulmonary Alveoli - metabolism</topic><topic>Smoking</topic><topic>Technetium</topic><topic>Technetium Tc 99m Pentetate</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jones, J G</creatorcontrib><creatorcontrib>Minty, B D</creatorcontrib><creatorcontrib>Royston, D</creatorcontrib><creatorcontrib>Royston, J P</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Thorax</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jones, J G</au><au>Minty, B D</au><au>Royston, D</au><au>Royston, J P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carboxyhaemoglobin and pulmonary epithelial permeability in man</atitle><jtitle>Thorax</jtitle><addtitle>Thorax</addtitle><date>1983-02-01</date><risdate>1983</risdate><volume>38</volume><issue>2</issue><spage>129</spage><epage>133</epage><pages>129-133</pages><issn>0040-6376</issn><eissn>1468-3296</eissn><coden>THORA7</coden><abstract>The effect of cigarette smoke exposure on pulmonary epithelial permeability was studied in 45 smokers and 22 non-smokers. An index of cigarette smoke exposure was obtained from the carboxyhaemoglobin concentration (HbCO%). Pulmonary epithelial permeability was proportional to the half-time clearance rate of technetium-99m-labelled diethylene triamine pentacetate (99mTc DTPA) from lung to blood (T1/2LB). The relationship between T1/2LB and HbCO% was hyperbolic in form and the data could be fitted to the quadratic formula (formula; see text) where the parameters a0, a1, and a2 represent respectively the asymptotic T1/2LB value at large carboxyhaemoglobin values and the slope and shape of the curve. The values of these parameters were a0 4.4 (2.6), a1 = 77.8 (15.5), and a2 -25.5 (9.7) (SE). This is the first demonstration of a dose-response relationship between carboxyhaemoglobin and an increased permeability of the lungs in man and provides a technique for identifying the roles of carbon monoxide and other cigarette smoke constituents in causing increased pulmonary epithelial permeability.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and British Thoracic Society</pub><pmid>6344310</pmid><doi>10.1136/thx.38.2.129</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0040-6376
ispartof Thorax, 1983-02, Vol.38 (2), p.129-133
issn 0040-6376
1468-3296
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_459501
source PubMed (Medline); MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library
subjects Adult
Aged
Carboxyhemoglobin - analysis
Cell Membrane Permeability
Hemoglobins - analysis
Humans
Middle Aged
Pentetic Acid
Pulmonary Alveoli - metabolism
Smoking
Technetium
Technetium Tc 99m Pentetate
Time Factors
title Carboxyhaemoglobin and pulmonary epithelial permeability in man
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T23%3A59%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Carboxyhaemoglobin%20and%20pulmonary%20epithelial%20permeability%20in%20man&rft.jtitle=Thorax&rft.au=Jones,%20J%20G&rft.date=1983-02-01&rft.volume=38&rft.issue=2&rft.spage=129&rft.epage=133&rft.pages=129-133&rft.issn=0040-6376&rft.eissn=1468-3296&rft.coden=THORA7&rft_id=info:doi/10.1136/thx.38.2.129&rft_dat=%3Cproquest_pubme%3E80510893%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1771299953&rft_id=info:pmid/6344310&rfr_iscdi=true