Interstitial lung disease and asthma in hard-metal workers: bronchoalveolar lavage, ultrastructural, and analytical findings and results of bronchial provocation tests
Five patients with respiratory disorders associated with hard metal exposure are described. In four patients electron microprobe analysis of bronchoalveolar lavage cells or lung tissue was used to show tungsten and other hard-metal components. Three patients had interstitial pneumonia and fibrosis w...
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| Veröffentlicht in: | Thorax 1983-02, Vol.38 (2), p.119-128 |
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| container_title | Thorax |
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| creator | Davison, A G Haslam, P L Corrin, B Coutts, I I Dewar, A Riding, W D Studdy, P R Newman-Taylor, A J |
| description | Five patients with respiratory disorders associated with hard metal exposure are described. In four patients electron microprobe analysis of bronchoalveolar lavage cells or lung tissue was used to show tungsten and other hard-metal components. Three patients had interstitial pneumonia and fibrosis with unusual multinucleate giant cells. Electron microscopy showed that the giant cells comprised both type II alveolar epithelial cells and alveolar macrophages. The multinucleate macrophages formed a distinctive feature of the bronchoalveolar lavage material but the multinucleate alveolar epithelial lining cells were evident only in lung tissue. The other two patients both suffered from work-related asthma, one of whom also had pulmonary opacities. Bronchial provocation tests in these patients supported the diagnosis of hard-metal-induced asthma and implicated cobalt as the agent responsible. |
| doi_str_mv | 10.1136/thx.38.2.119 |
| format | Article |
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In four patients electron microprobe analysis of bronchoalveolar lavage cells or lung tissue was used to show tungsten and other hard-metal components. Three patients had interstitial pneumonia and fibrosis with unusual multinucleate giant cells. Electron microscopy showed that the giant cells comprised both type II alveolar epithelial cells and alveolar macrophages. The multinucleate macrophages formed a distinctive feature of the bronchoalveolar lavage material but the multinucleate alveolar epithelial lining cells were evident only in lung tissue. The other two patients both suffered from work-related asthma, one of whom also had pulmonary opacities. Bronchial provocation tests in these patients supported the diagnosis of hard-metal-induced asthma and implicated cobalt as the agent responsible.</description><identifier>ISSN: 0040-6376</identifier><identifier>EISSN: 1468-3296</identifier><identifier>DOI: 10.1136/thx.38.2.119</identifier><identifier>PMID: 6857569</identifier><identifier>CODEN: THORA7</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and British Thoracic Society</publisher><subject>Adult ; Asthma - chemically induced ; Asthma - pathology ; Bronchial Provocation Tests ; Cell Count ; Cobalt - adverse effects ; Female ; Humans ; Lung - ultrastructure ; Lung Volume Measurements ; Male ; Metallurgy ; Microscopy, Electron ; Middle Aged ; Occupational Diseases - chemically induced ; Occupational Diseases - pathology ; Pulmonary Fibrosis - chemically induced ; Pulmonary Fibrosis - pathology ; Therapeutic Irrigation</subject><ispartof>Thorax, 1983-02, Vol.38 (2), p.119-128</ispartof><rights>Copyright BMJ Publishing Group LTD Feb 1983</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b542t-39cee2e61a414fc5e1d3f40091c0401dbb63fe22a7ac962d45575d279be1215a3</citedby><cites>FETCH-LOGICAL-b542t-39cee2e61a414fc5e1d3f40091c0401dbb63fe22a7ac962d45575d279be1215a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC459500/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC459500/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6857569$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Davison, A G</creatorcontrib><creatorcontrib>Haslam, P L</creatorcontrib><creatorcontrib>Corrin, B</creatorcontrib><creatorcontrib>Coutts, I I</creatorcontrib><creatorcontrib>Dewar, A</creatorcontrib><creatorcontrib>Riding, W D</creatorcontrib><creatorcontrib>Studdy, P R</creatorcontrib><creatorcontrib>Newman-Taylor, A J</creatorcontrib><title>Interstitial lung disease and asthma in hard-metal workers: bronchoalveolar lavage, ultrastructural, and analytical findings and results of bronchial provocation tests</title><title>Thorax</title><addtitle>Thorax</addtitle><description>Five patients with respiratory disorders associated with hard metal exposure are described. In four patients electron microprobe analysis of bronchoalveolar lavage cells or lung tissue was used to show tungsten and other hard-metal components. Three patients had interstitial pneumonia and fibrosis with unusual multinucleate giant cells. Electron microscopy showed that the giant cells comprised both type II alveolar epithelial cells and alveolar macrophages. The multinucleate macrophages formed a distinctive feature of the bronchoalveolar lavage material but the multinucleate alveolar epithelial lining cells were evident only in lung tissue. The other two patients both suffered from work-related asthma, one of whom also had pulmonary opacities. Bronchial provocation tests in these patients supported the diagnosis of hard-metal-induced asthma and implicated cobalt as the agent responsible.</description><subject>Adult</subject><subject>Asthma - chemically induced</subject><subject>Asthma - pathology</subject><subject>Bronchial Provocation Tests</subject><subject>Cell Count</subject><subject>Cobalt - adverse effects</subject><subject>Female</subject><subject>Humans</subject><subject>Lung - ultrastructure</subject><subject>Lung Volume Measurements</subject><subject>Male</subject><subject>Metallurgy</subject><subject>Microscopy, Electron</subject><subject>Middle Aged</subject><subject>Occupational Diseases - chemically induced</subject><subject>Occupational Diseases - pathology</subject><subject>Pulmonary Fibrosis - chemically induced</subject><subject>Pulmonary Fibrosis - pathology</subject><subject>Therapeutic Irrigation</subject><issn>0040-6376</issn><issn>1468-3296</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kctu1DAUhiMEKtPCji2SJRZsJoMviRMjdYEGKEUVsIBurZPEmXjq2IPtTNsn4jVxyWgEG1bW8f_955plLwheEcL4mzjcrVi9oikSj7IFKXidMyr442yBcYFzzir-NDsNYYsxrgmpTrITXpdVycUi-3Vpo_Ih6qjBIDPZDep0UBAUAtshCHEYAWmLBvBdPqqYqFvnb5LnLWq8s-3gwOyVM-CRgT1s1BJNJvrk9FMbJw9mOaeyYO6jblOCXttO20348-9VSHxArj_ke2hk593etRC1syiqEMOz7EkPJqjnh_cs-_Hxw_f1p_zq68Xl-t1V3pQFjTkTrVJUcQIFKfq2VKRjfYGxIG1aBemahrNeUQoVtILTrijTHjpaiUYRSkpgZ9n5nHc3NaPqWmXTKEbuvB7B30sHWv6rWD3IjdvLohQlxsn_6uD37ueUOpdbN_k0epCkqggVoipYopYz1XoXglf9sQDB8uGoMh1VslrSFImEv_y7qSN8uGLS81nXIaq7owz-RvKKVaX8cr2W7-nnktXfLuR14l_PfDNu_1_5N2o4vyw</recordid><startdate>19830201</startdate><enddate>19830201</enddate><creator>Davison, A G</creator><creator>Haslam, P L</creator><creator>Corrin, B</creator><creator>Coutts, I I</creator><creator>Dewar, A</creator><creator>Riding, W D</creator><creator>Studdy, P R</creator><creator>Newman-Taylor, A J</creator><general>BMJ Publishing Group Ltd and British Thoracic Society</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>19830201</creationdate><title>Interstitial lung disease and asthma in hard-metal workers: bronchoalveolar lavage, ultrastructural, and analytical findings and results of bronchial provocation tests</title><author>Davison, A G ; Haslam, P L ; Corrin, B ; Coutts, I I ; Dewar, A ; Riding, W D ; Studdy, P R ; Newman-Taylor, A J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b542t-39cee2e61a414fc5e1d3f40091c0401dbb63fe22a7ac962d45575d279be1215a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adult</topic><topic>Asthma - chemically induced</topic><topic>Asthma - pathology</topic><topic>Bronchial Provocation Tests</topic><topic>Cell Count</topic><topic>Cobalt - adverse effects</topic><topic>Female</topic><topic>Humans</topic><topic>Lung - ultrastructure</topic><topic>Lung Volume Measurements</topic><topic>Male</topic><topic>Metallurgy</topic><topic>Microscopy, Electron</topic><topic>Middle Aged</topic><topic>Occupational Diseases - chemically induced</topic><topic>Occupational Diseases - pathology</topic><topic>Pulmonary Fibrosis - chemically induced</topic><topic>Pulmonary Fibrosis - pathology</topic><topic>Therapeutic Irrigation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Davison, A G</creatorcontrib><creatorcontrib>Haslam, P L</creatorcontrib><creatorcontrib>Corrin, B</creatorcontrib><creatorcontrib>Coutts, I I</creatorcontrib><creatorcontrib>Dewar, A</creatorcontrib><creatorcontrib>Riding, W D</creatorcontrib><creatorcontrib>Studdy, P R</creatorcontrib><creatorcontrib>Newman-Taylor, A J</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Thorax</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Davison, A G</au><au>Haslam, P L</au><au>Corrin, B</au><au>Coutts, I I</au><au>Dewar, A</au><au>Riding, W D</au><au>Studdy, P R</au><au>Newman-Taylor, A J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interstitial lung disease and asthma in hard-metal workers: bronchoalveolar lavage, ultrastructural, and analytical findings and results of bronchial provocation tests</atitle><jtitle>Thorax</jtitle><addtitle>Thorax</addtitle><date>1983-02-01</date><risdate>1983</risdate><volume>38</volume><issue>2</issue><spage>119</spage><epage>128</epage><pages>119-128</pages><issn>0040-6376</issn><eissn>1468-3296</eissn><coden>THORA7</coden><abstract>Five patients with respiratory disorders associated with hard metal exposure are described. In four patients electron microprobe analysis of bronchoalveolar lavage cells or lung tissue was used to show tungsten and other hard-metal components. Three patients had interstitial pneumonia and fibrosis with unusual multinucleate giant cells. Electron microscopy showed that the giant cells comprised both type II alveolar epithelial cells and alveolar macrophages. The multinucleate macrophages formed a distinctive feature of the bronchoalveolar lavage material but the multinucleate alveolar epithelial lining cells were evident only in lung tissue. The other two patients both suffered from work-related asthma, one of whom also had pulmonary opacities. Bronchial provocation tests in these patients supported the diagnosis of hard-metal-induced asthma and implicated cobalt as the agent responsible.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and British Thoracic Society</pub><pmid>6857569</pmid><doi>10.1136/thx.38.2.119</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Thorax, 1983-02, Vol.38 (2), p.119-128 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Asthma - chemically induced Asthma - pathology Bronchial Provocation Tests Cell Count Cobalt - adverse effects Female Humans Lung - ultrastructure Lung Volume Measurements Male Metallurgy Microscopy, Electron Middle Aged Occupational Diseases - chemically induced Occupational Diseases - pathology Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - pathology Therapeutic Irrigation |
| title | Interstitial lung disease and asthma in hard-metal workers: bronchoalveolar lavage, ultrastructural, and analytical findings and results of bronchial provocation tests |
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