Alleviation of skin inflammation after Lin− cell transplantation correlates with their differentiation into myeloid-derived suppressor cells

To understand the cellular mechanism underlying the therapeutic effects exerted by hematopoietic stem cell transplantation in the repair of tissue damage, we investigated the in vivo dynamics of bone marrow (BM) lineage-negative (Lin − ) cells transplanted into mice with hyper sensitivity dermatitis...

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Veröffentlicht in:	Scientific reports 2015-10, Vol.5 (1), p.14663-14663, Article 14663
Hauptverfasser:	Jeong Ryu, Su, Ju, Ji-Min, Kim, Woojin, Bum Kim, Min, Hee Oh, Kuen, Sup Lee, Dong, Lee, Hakmo, Eun Oh, Ju, Soo Park, Kyong, Young Choi, Eun
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/31 38/5 631/532/1360 631/532/1542 64/110 64/60 Animals Arginase Blotting, Western Bone marrow Bone Marrow Cells Bone marrow transplantation CD11b antigen CD3 antigen CD4 antigen CD8 antigen Cell Differentiation Cells, Cultured Dermatitis Dermatitis - etiology Dermatitis - pathology Dermatitis - prevention & control Dinitrochlorobenzene - toxicity Flow cytometry Hematopoietic Stem Cell Transplantation Humanities and Social Sciences Humans Immunoenzyme Techniques Inflammation Interleukin 10 Irritants - toxicity Leukocytes (neutrophilic) Macrophages Mice Mice, Inbred C57BL Mice, Transgenic multidisciplinary Myeloid Cells - cytology Myeloid Cells - immunology Nitric-oxide synthase Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Rodents Science Skin Stem cell transplantation Stem cells Suppressor cells Transcription Transplantation
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