Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma

B-cell lymphomas frequently contain genomic rearrangements that lead to oncogene activation by heterologous distal regulatory elements. We used a novel approach called "pinpointing enhancer-associated rearrangements by chromatin immunoprecipitation," or PEAR-ChIP, to simultaneously map enh...

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Veröffentlicht in:	Cancer discovery 2015-10, Vol.5 (10), p.1058-1071
Hauptverfasser:	Ryan, Russell J H, Drier, Yotam, Whitton, Holly, Cotton, M Joel, Kaur, Jasleen, Issner, Robbyn, Gillespie, Shawn, Epstein, Charles B, Nardi, Valentina, Sohani, Aliyah R, Hochberg, Ephraim P, Bernstein, Bradley E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Cell Line, Tumor Chromatin Immunoprecipitation Chromosomes, Human, Pair 3 Chromosomes, Human, Pair 8 DNA-Binding Proteins - genetics Enhancer Elements, Genetic Gene Duplication Gene Expression Regulation, Neoplastic Gene Rearrangement Genes, myc Genetic Predisposition to Disease Genome-Wide Association Study High-Throughput Nucleotide Sequencing Histones - metabolism Humans Lymphoma, B-Cell - diagnosis Lymphoma, B-Cell - genetics Lymphoma, B-Cell - metabolism Lymphoma, Mantle-Cell - diagnosis Lymphoma, Mantle-Cell - genetics MEF2 Transcription Factors - metabolism Oncogenes p300-CBP Transcription Factors - metabolism Polymorphism, Genetic Protein Binding Proto-Oncogene Proteins c-bcl-6 Recombination, Genetic Translocation, Genetic
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