Platelet-derived VWF in the stroke spotlight

In this issue of Blood, Verhenne et al present data showing the role of platelet-derived von Willebrand factor (VWF) in mediating ischemic stroke injury using a murine model. They created mice with either endothelial VWF or platelet-derived VWF and examined each phenotype for bleeding and thrombosis...

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Veröffentlicht in:Blood 2015-10, Vol.126 (14), p.1640-1641
1. Verfasser: Flood, Veronica H.
Format: Artikel
Sprache:eng
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Zusammenfassung:In this issue of Blood, Verhenne et al present data showing the role of platelet-derived von Willebrand factor (VWF) in mediating ischemic stroke injury using a murine model. They created mice with either endothelial VWF or platelet-derived VWF and examined each phenotype for bleeding and thrombosis. Their intriguing findings were that mice lacking platelet-derived VWF, but with adequate endothelial VWF stores, demonstrated normal hemostasis in a tail bleeding model and normal carotid artery thrombosis. Mice with only platelet-derived VWF had defective hemostasis and defective carotid artery thrombosis, but experienced significant cerebral infarction using a stroke model with middle cerebral artery occlusion (see figure). In contrast, minimal infarcts were seen for VWF-deficient mice. These data suggest that platelet-derived VWF plays a specific role in stroke pathology.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2015-08-661439