Impact of flanking chromosomal sequences on localization and silencing by the human non-coding RNA XIST

X-chromosome inactivation is a striking example of epigenetic silencing in which expression of the long non-coding RNA XIST initiates the heterochromatinization and silencing of one of the pair of X chromosomes in mammalian females. To understand how the RNA can establish silencing across millions o...

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Veröffentlicht in:	Genome Biology 2015-10, Vol.16 (1), p.208-208, Article 208
Hauptverfasser:	Kelsey, Angela D, Yang, Christine, Leung, Danny, Minks, Jakub, Dixon-McDougall, Thomas, Baldry, Sarah E L, Bogutz, Aaron B, Lefebvre, Louis, Brown, Carolyn J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Base pairs Chromatin Chromosomes Chromosomes, Human, X - genetics Deoxyribonucleic acid DNA DNA methylation Epigenesis, Genetic Epigenetic inheritance Female Gene Expression Regulation, Developmental Gene Silencing Gene therapy Genes Genome, Human Genomes Heterochromatin Heterochromatin - genetics Humans Localization Mammals Methods Non-coding RNA Physiological aspects Regulatory sequences RNA RNA, Long Noncoding - genetics RNA-mediated interference Stem cells Ubiquitination X Chromosome Inactivation - genetics X chromosomes X-chromosome inactivation
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