Effects of Combined Exposure to Lead and High-Fat Diet on Bone Quality in Juvenile Male Mice

Lead (Pb) exposure and obesity are co-occurring risk factors for decreased bone mass in the young, particularly in low socioeconomic communities. The goal of this study was to determine whether the comorbidities of Pb exposure and high-fat diet-induced obesity amplify skeletal deficits independently...

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Veröffentlicht in:	Environmental health perspectives 2015-10, Vol.123 (10), p.935-935
Hauptverfasser:	Beier, Eric E, Inzana, Jason A, Sheu, Tzong-Jen, Shu, Lei, Puzas, J Edward, Mooney, Robert A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical materials Body fat Bone density Bone Development - drug effects Bone marrow Bones Care and treatment Cell differentiation Density Diet Diet, High-Fat - adverse effects Diets Drinking water Environmental Pollutants - toxicity Exposure Fatty acids Genotype & phenotype Health Health aspects Inertia Ketogenic diet Lead (metal) Lead - toxicity Male Mesenchymal Stromal Cells - drug effects Mice Mice, Inbred C57BL Nutrition Obesity Obesity - chemically induced Osteoporosis Pediatrics Proteins Rats as laboratory animals Risk analysis Risk factors Studies Toxicants Transcription factors Wnt Signaling Pathway - drug effects
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