Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy

Autophagy represents an intracellular degradation process which is involved in both regular cell homeostasis and disease settings. In recent years, the molecular machinery governing this process has been elucidated. The ULK1 kinase complex consisting of the serine/threonine protein kinase ULK1 and t...

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Veröffentlicht in:	Autophagy 2015, Vol.11 (9), p.1458-1470
Hauptverfasser:	Drießen, Stefan, Berleth, Niklas, Friesen, Olena, Löffler, Antje S, Böhler, Philip, Hieke, Nora, Stuhldreier, Fabian, Peter, Christoph, Schink, Kay O, Schultz, Sebastian W, Stenmark, Harald, Holland, Petter, Simonsen, Anne, Wesselborg, Sebastian, Stork, Björn
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy - drug effects Autophagy-Related Protein-1 Homolog Basic Brief Report Cyanoacrylates - pharmacology Green Fluorescent Proteins - metabolism HEK293 Cells HeLa Cells Humans Intracellular Signaling Peptides and Proteins - metabolism Protein Aggregates - drug effects Protein-Serine-Threonine Kinases - metabolism Pyridines - pharmacology Ubiquitin-Specific Proteases - antagonists & inhibitors Ubiquitination - drug effects
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