Correlation Between Nuclear Factor E2-Related Factor 2 Expression and Gastric Cancer Progression
Nuclear factor E2-related factor 2 (Nrf2) plays an anti-oxidative and phase II detoxification function via its up-regulation on various antioxidant response elements (ARE) genes. Nrf2 can protect both normal and cancer cells from damages of cell stress, thereby exerting a critical role in the develo...
Gespeichert in:
| Veröffentlicht in: | Medical science monitor 2015-09, Vol.21, p.2893-2899 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2899 |
|---|---|
| container_issue | |
| container_start_page | 2893 |
| container_title | Medical science monitor |
| container_volume | 21 |
| creator | Zheng, Hongyu Nong, Zhiwei Lu, Guohao |
| description | Nuclear factor E2-related factor 2 (Nrf2) plays an anti-oxidative and phase II detoxification function via its up-regulation on various antioxidant response elements (ARE) genes. Nrf2 can protect both normal and cancer cells from damages of cell stress, thereby exerting a critical role in the development of cancer. The expression and significance of Nrf2 in gastric cancer, however, has not been reported. This study thus aimed to investigate the expression of Nrf2 in gastric cancer tissues via immunohistochemical (IHC) staining.
Gastric carcinoma tissues from a total of 175 patients during surgical resection were examined for Nfr2 expression profiles using IHC staining on paraffin-embedded slides. Between-group-comparisons were performed by chi-square, Fisher's exact, or Mann-Whitney U test. The correlation between Nfr2 expression and clinical indexes was further analyzed by Kaplan-Meier test, univariate/multivariate analysis, and log-rank test.
Nrf2 is mainly expressed in nuclei of gastric carcinoma tissues, with significant correlation with clinical indexes, including tumor size, invasive depth, lymph node metastasis, and invasion. Patients with Nrf2-positive expression had significantly lower survival rates compared to those in the negative group (p |
| doi_str_mv | 10.12659/MSM.894467 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4590579</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1718074061</sourcerecordid><originalsourceid>FETCH-LOGICAL-c447t-113891a5ad8fbf3aca36d16e6b808b1938c6b8e32a911e7b6f8a341697668d813</originalsourceid><addsrcrecordid>eNpVUctOwzAQtBCIR-HEHeWIhALe2HGcCxJULSBRQDzOZuNsICiNi53y-HtaWhCcdrQzO7PSMLYL_BASleZHo7vRoc6lVNkK2wQlRSyylK_-wRtsK4QXzhOteLrONhIlgYPSm-yx77ynBrvatdEpde9EbXQ1tQ2hj4ZoO-ejQRLfziVU_mySaPAx8RTC_ArbMjrD0PnaRn1sLfnoxrunJb3N1ipsAu0sZ489DAf3_fP48vrson9yGVspsy4GEDoHTLHUVVEJtChUCYpUobkuIBfaziCJBHMAygpVaRQSVJ4ppUsNoseOF76TaTGm0lLbeWzMxNdj9J_GYW3-M239bJ7cm5FpztMsnxnsLw28e51S6My4DpaaBlty02AgA80zydU862Ahtd6F4Kn6jQFuvjsxs07MopOZeu_vZ7_anxLEFziBh8A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1718074061</pqid></control><display><type>article</type><title>Correlation Between Nuclear Factor E2-Related Factor 2 Expression and Gastric Cancer Progression</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Zheng, Hongyu ; Nong, Zhiwei ; Lu, Guohao</creator><creatorcontrib>Zheng, Hongyu ; Nong, Zhiwei ; Lu, Guohao</creatorcontrib><description>Nuclear factor E2-related factor 2 (Nrf2) plays an anti-oxidative and phase II detoxification function via its up-regulation on various antioxidant response elements (ARE) genes. Nrf2 can protect both normal and cancer cells from damages of cell stress, thereby exerting a critical role in the development of cancer. The expression and significance of Nrf2 in gastric cancer, however, has not been reported. This study thus aimed to investigate the expression of Nrf2 in gastric cancer tissues via immunohistochemical (IHC) staining.
Gastric carcinoma tissues from a total of 175 patients during surgical resection were examined for Nfr2 expression profiles using IHC staining on paraffin-embedded slides. Between-group-comparisons were performed by chi-square, Fisher's exact, or Mann-Whitney U test. The correlation between Nfr2 expression and clinical indexes was further analyzed by Kaplan-Meier test, univariate/multivariate analysis, and log-rank test.
Nrf2 is mainly expressed in nuclei of gastric carcinoma tissues, with significant correlation with clinical indexes, including tumor size, invasive depth, lymph node metastasis, and invasion. Patients with Nrf2-positive expression had significantly lower survival rates compared to those in the negative group (p<0.01), with chemo-resistance against 5-fluorouracil (5-FU) (p<0.05).
Nrf2 expression is positively correlated with invasive gastric cancer, suggesting its utility as a predictive index for unfavorable prognosis.</description><identifier>ISSN: 1643-3750</identifier><identifier>ISSN: 1234-1010</identifier><identifier>EISSN: 1643-3750</identifier><identifier>DOI: 10.12659/MSM.894467</identifier><identifier>PMID: 26410168</identifier><language>eng</language><publisher>United States: International Scientific Literature, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents - therapeutic use ; Antioxidants - chemistry ; Carcinoma - metabolism ; Clinical Research ; Drug Resistance, Neoplasm ; Female ; Fluorouracil - therapeutic use ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Lymphatic Metastasis ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Invasiveness ; NF-E2-Related Factor 2 - metabolism ; Prognosis ; Response Elements ; Stomach Neoplasms - metabolism ; Up-Regulation</subject><ispartof>Medical science monitor, 2015-09, Vol.21, p.2893-2899</ispartof><rights>Med Sci Monit, 2015 2015</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-113891a5ad8fbf3aca36d16e6b808b1938c6b8e32a911e7b6f8a341697668d813</citedby><cites>FETCH-LOGICAL-c447t-113891a5ad8fbf3aca36d16e6b808b1938c6b8e32a911e7b6f8a341697668d813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590579/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590579/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26410168$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zheng, Hongyu</creatorcontrib><creatorcontrib>Nong, Zhiwei</creatorcontrib><creatorcontrib>Lu, Guohao</creatorcontrib><title>Correlation Between Nuclear Factor E2-Related Factor 2 Expression and Gastric Cancer Progression</title><title>Medical science monitor</title><addtitle>Med Sci Monit</addtitle><description>Nuclear factor E2-related factor 2 (Nrf2) plays an anti-oxidative and phase II detoxification function via its up-regulation on various antioxidant response elements (ARE) genes. Nrf2 can protect both normal and cancer cells from damages of cell stress, thereby exerting a critical role in the development of cancer. The expression and significance of Nrf2 in gastric cancer, however, has not been reported. This study thus aimed to investigate the expression of Nrf2 in gastric cancer tissues via immunohistochemical (IHC) staining.
Gastric carcinoma tissues from a total of 175 patients during surgical resection were examined for Nfr2 expression profiles using IHC staining on paraffin-embedded slides. Between-group-comparisons were performed by chi-square, Fisher's exact, or Mann-Whitney U test. The correlation between Nfr2 expression and clinical indexes was further analyzed by Kaplan-Meier test, univariate/multivariate analysis, and log-rank test.
Nrf2 is mainly expressed in nuclei of gastric carcinoma tissues, with significant correlation with clinical indexes, including tumor size, invasive depth, lymph node metastasis, and invasion. Patients with Nrf2-positive expression had significantly lower survival rates compared to those in the negative group (p<0.01), with chemo-resistance against 5-fluorouracil (5-FU) (p<0.05).
Nrf2 expression is positively correlated with invasive gastric cancer, suggesting its utility as a predictive index for unfavorable prognosis.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Antioxidants - chemistry</subject><subject>Carcinoma - metabolism</subject><subject>Clinical Research</subject><subject>Drug Resistance, Neoplasm</subject><subject>Female</subject><subject>Fluorouracil - therapeutic use</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Kaplan-Meier Estimate</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Invasiveness</subject><subject>NF-E2-Related Factor 2 - metabolism</subject><subject>Prognosis</subject><subject>Response Elements</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Up-Regulation</subject><issn>1643-3750</issn><issn>1234-1010</issn><issn>1643-3750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUctOwzAQtBCIR-HEHeWIhALe2HGcCxJULSBRQDzOZuNsICiNi53y-HtaWhCcdrQzO7PSMLYL_BASleZHo7vRoc6lVNkK2wQlRSyylK_-wRtsK4QXzhOteLrONhIlgYPSm-yx77ynBrvatdEpde9EbXQ1tQ2hj4ZoO-ejQRLfziVU_mySaPAx8RTC_ArbMjrD0PnaRn1sLfnoxrunJb3N1ipsAu0sZ489DAf3_fP48vrson9yGVspsy4GEDoHTLHUVVEJtChUCYpUobkuIBfaziCJBHMAygpVaRQSVJ4ppUsNoseOF76TaTGm0lLbeWzMxNdj9J_GYW3-M239bJ7cm5FpztMsnxnsLw28e51S6My4DpaaBlty02AgA80zydU862Ahtd6F4Kn6jQFuvjsxs07MopOZeu_vZ7_anxLEFziBh8A</recordid><startdate>20150927</startdate><enddate>20150927</enddate><creator>Zheng, Hongyu</creator><creator>Nong, Zhiwei</creator><creator>Lu, Guohao</creator><general>International Scientific Literature, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150927</creationdate><title>Correlation Between Nuclear Factor E2-Related Factor 2 Expression and Gastric Cancer Progression</title><author>Zheng, Hongyu ; Nong, Zhiwei ; Lu, Guohao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-113891a5ad8fbf3aca36d16e6b808b1938c6b8e32a911e7b6f8a341697668d813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Antioxidants - chemistry</topic><topic>Carcinoma - metabolism</topic><topic>Clinical Research</topic><topic>Drug Resistance, Neoplasm</topic><topic>Female</topic><topic>Fluorouracil - therapeutic use</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Kaplan-Meier Estimate</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Invasiveness</topic><topic>NF-E2-Related Factor 2 - metabolism</topic><topic>Prognosis</topic><topic>Response Elements</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Up-Regulation</topic><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Hongyu</creatorcontrib><creatorcontrib>Nong, Zhiwei</creatorcontrib><creatorcontrib>Lu, Guohao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medical science monitor</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Hongyu</au><au>Nong, Zhiwei</au><au>Lu, Guohao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation Between Nuclear Factor E2-Related Factor 2 Expression and Gastric Cancer Progression</atitle><jtitle>Medical science monitor</jtitle><addtitle>Med Sci Monit</addtitle><date>2015-09-27</date><risdate>2015</risdate><volume>21</volume><spage>2893</spage><epage>2899</epage><pages>2893-2899</pages><issn>1643-3750</issn><issn>1234-1010</issn><eissn>1643-3750</eissn><abstract>Nuclear factor E2-related factor 2 (Nrf2) plays an anti-oxidative and phase II detoxification function via its up-regulation on various antioxidant response elements (ARE) genes. Nrf2 can protect both normal and cancer cells from damages of cell stress, thereby exerting a critical role in the development of cancer. The expression and significance of Nrf2 in gastric cancer, however, has not been reported. This study thus aimed to investigate the expression of Nrf2 in gastric cancer tissues via immunohistochemical (IHC) staining.
Gastric carcinoma tissues from a total of 175 patients during surgical resection were examined for Nfr2 expression profiles using IHC staining on paraffin-embedded slides. Between-group-comparisons were performed by chi-square, Fisher's exact, or Mann-Whitney U test. The correlation between Nfr2 expression and clinical indexes was further analyzed by Kaplan-Meier test, univariate/multivariate analysis, and log-rank test.
Nrf2 is mainly expressed in nuclei of gastric carcinoma tissues, with significant correlation with clinical indexes, including tumor size, invasive depth, lymph node metastasis, and invasion. Patients with Nrf2-positive expression had significantly lower survival rates compared to those in the negative group (p<0.01), with chemo-resistance against 5-fluorouracil (5-FU) (p<0.05).
Nrf2 expression is positively correlated with invasive gastric cancer, suggesting its utility as a predictive index for unfavorable prognosis.</abstract><cop>United States</cop><pub>International Scientific Literature, Inc</pub><pmid>26410168</pmid><doi>10.12659/MSM.894467</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1643-3750 |
| ispartof | Medical science monitor, 2015-09, Vol.21, p.2893-2899 |
| issn | 1643-3750 1234-1010 1643-3750 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4590579 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Adult Aged Aged, 80 and over Antineoplastic Agents - therapeutic use Antioxidants - chemistry Carcinoma - metabolism Clinical Research Drug Resistance, Neoplasm Female Fluorouracil - therapeutic use Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Kaplan-Meier Estimate Lymphatic Metastasis Male Middle Aged Multivariate Analysis Neoplasm Invasiveness NF-E2-Related Factor 2 - metabolism Prognosis Response Elements Stomach Neoplasms - metabolism Up-Regulation |
| title | Correlation Between Nuclear Factor E2-Related Factor 2 Expression and Gastric Cancer Progression |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T23%3A12%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Correlation%20Between%20Nuclear%20Factor%20E2-Related%20Factor%202%20Expression%20and%20Gastric%20Cancer%20Progression&rft.jtitle=Medical%20science%20monitor&rft.au=Zheng,%20Hongyu&rft.date=2015-09-27&rft.volume=21&rft.spage=2893&rft.epage=2899&rft.pages=2893-2899&rft.issn=1643-3750&rft.eissn=1643-3750&rft_id=info:doi/10.12659/MSM.894467&rft_dat=%3Cproquest_pubme%3E1718074061%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1718074061&rft_id=info:pmid/26410168&rfr_iscdi=true |