Liver epithelial cells proliferate under hypoxia and protect the liver from ischemic injury via expression of HIF-1 alpha target genes

Background The remnant liver after extended liver resection is susceptible to ischemic injury, resulting in the failure of liver regeneration and liver dysfunction. The present study is aimed to investigate the protective role of the liver epithelial cells (LEC), a liver progenitor cell, on hepatocy...

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Veröffentlicht in:	Surgery 2012-11, Vol.152 (5), p.869-878
Hauptverfasser:	Abe, Yuki, MD, Uchinami, Hiroshi, MD, PhD, Kudoh, Kazuhiro, MD, Nakagawa, Yasuhiko, MD, Ise, Norihito, MD, Watanabe, Go, MD, Sato, Tsutomu, MD, Seki, Ekihiro, MD, Yamamoto, Yuzo, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Biological and medical sciences Cell Differentiation Cell Hypoxia Cell Proliferation Cell Survival Cells, Cultured Chemokine CXCL12 - metabolism General aspects Hepatocytes - physiology Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Ischemia - prevention & control Liver - blood supply Liver - cytology Liver - metabolism Liver Diseases - prevention & control Liver Regeneration Male Medical sciences Paracrine Communication Protein-Serine-Threonine Kinases - metabolism Rats Rats, Sprague-Dawley Receptors, CXCR4 - metabolism Surgery Up-Regulation
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