There is Kisspeptin – And Then There is Kisspeptin
While kisspeptin was initially found to function as a metastasis suppressor, after identification of its receptor KISS1R and their expression profiles in tissues such as the hypothalamus and adrenals, kisspeptin and KISS1R were predominantly assigned endocrine functions, including regulating puberty...
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| Veröffentlicht in: | Trends in endocrinology and metabolism 2015-10, Vol.26 (10), p.564-572 |
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| creator | Hussain, Mehboob A Song, Woo-Jin Wolfe, Andrew |
| description | While kisspeptin was initially found to function as a metastasis suppressor, after identification of its receptor KISS1R and their expression profiles in tissues such as the hypothalamus and adrenals, kisspeptin and KISS1R were predominantly assigned endocrine functions, including regulating puberty and fertility through their actions on hypothalamic gonadotropin releasing hormone production. More recently, an alter ego for kisspeptin has emerged, with a significant role in regulating glucose homeostasis, insulin secretion, as well as food intake and body composition, and deficient kisspeptin signaling results in reduced locomotor activity and increased adiposity. This review highlights these recent observations on the role of kisspeptin in metabolism as well as several key questions that need to be addressed in the future. |
| doi_str_mv | 10.1016/j.tem.2015.07.008 |
| format | Article |
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More recently, an alter ego for kisspeptin has emerged, with a significant role in regulating glucose homeostasis, insulin secretion, as well as food intake and body composition, and deficient kisspeptin signaling results in reduced locomotor activity and increased adiposity. 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| ispartof | Trends in endocrinology and metabolism, 2015-10, Vol.26 (10), p.564-572 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Endocrinology & Metabolism Female glucagon Glucagon - genetics Glucagon - metabolism Humans insulin Kisspeptin Kisspeptins - genetics Kisspeptins - metabolism Male obesity Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism satiety Satiety Response - physiology sexual dimorphism |
| title | There is Kisspeptin – And Then There is Kisspeptin |
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