Mesoporous silica nanoparticle delivery of chemically modified siRNA against TWIST1 leads to reduced tumor burden

Abstract Growth and progression of solid tumors depend on the integration of multiple pro-growth and survival signals, including the induction of angiogenesis. TWIST1 is a transcription factor whose reactivation in tumors leads to epithelial to mesenchymal transition (EMT), including increased cance...

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Veröffentlicht in:	Nanomedicine 2015-10, Vol.11 (7), p.1657-1666
Hauptverfasser:	Finlay, James, DVM, Roberts, Cai M., BS, Dong, Juyao, PhD, Zink, Jeffrey I., PhD, Tamanoi, Fuyuhiko, PhD, Glackin, Carlotta A., PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Cell Line, Tumor Gene Transfer Techniques Humans Internal Medicine Mesoporous silica Mice Nanoparticles - administration & dosage Nanoparticles - chemistry Neoplasms - genetics Neoplasms - pathology Neoplasms - therapy Neovascularization, Pathologic - genetics Neovascularization, Pathologic - therapy Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - genetics RNA, Small Interfering - administration & dosage RNA, Small Interfering - chemistry Silicon Dioxide - administration & dosage Silicon Dioxide - chemistry siRNA Tumor Burden - genetics Twist-Related Protein 1 - antagonists & inhibitors Twist-Related Protein 1 - genetics TWIST1 Xenograft Model Antitumor Assays
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